Publication detail

G4Killer web application: a tool to design G-quadruplex mutations

BRÁZDA, V. KOLOMAZNÍK, J. MERGNY, J. ŠŤASTNÝ, J.

Original Title

G4Killer web application: a tool to design G-quadruplex mutations

Type

journal article in Web of Science

Language

English

Original Abstract

G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. RESULTS: We developed a web-based tool termed G4Killer that is based on the G4Hunter algorithm. This new tool is a platform-independent and user-friendly application to design mutations crippling G4 propensity in a parsimonious way (i.e., keeping the primary sequence as close as possible to the original one). The tool is integrated into our DNA analyzer server and allows for generating mutated DNA sequences having the desired lowered G4Hunter score with minimal mutation steps. AVAILABILITY AND IMPLEMENTATION: The G4Killer web tool can be accessed at: http://bioinformatics.ibp.cz. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. © The Author(s) 2020. Published by Oxford University Press.

Keywords

G4Killer, G-quadruplex, web application

Authors

BRÁZDA, V.; KOLOMAZNÍK, J.; MERGNY, J.; ŠŤASTNÝ, J.

Released

15. 5. 2020

ISBN

1367-4803

Periodical

BIOINFORMATICS

Year of study

36

Number

10

State

United Kingdom of Great Britain and Northern Ireland

Pages from

3246

Pages to

3247

Pages count

2

URL

https://academic.oup.com/bioinformatics/article/36/10/3246/5716328

Full text in the Digital Library

http://hdl.handle.net/11012/194871

BibTex

@article{BUT164187,
  author="Václav {Brázda} and Jan {Kolomazník} and Jean-Louis {Mergny} and Jiří {Šťastný}",
  title="G4Killer web application: a tool to design G-quadruplex mutations",
  journal="BIOINFORMATICS",
  year="2020",
  volume="36",
  number="10",
  pages="3246--3247",
  doi="10.1093/bioinformatics/btaa057",
  issn="1367-4803",
  url="https://academic.oup.com/bioinformatics/article/36/10/3246/5716328"
}