Detail publikace

G4Killer web application: a tool to design G-quadruplex mutations

BRÁZDA, V. KOLOMAZNÍK, J. MERGNY, J. ŠŤASTNÝ, J.

Originální název

G4Killer web application: a tool to design G-quadruplex mutations

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

G-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. RESULTS: We developed a web-based tool termed G4Killer that is based on the G4Hunter algorithm. This new tool is a platform-independent and user-friendly application to design mutations crippling G4 propensity in a parsimonious way (i.e., keeping the primary sequence as close as possible to the original one). The tool is integrated into our DNA analyzer server and allows for generating mutated DNA sequences having the desired lowered G4Hunter score with minimal mutation steps. AVAILABILITY AND IMPLEMENTATION: The G4Killer web tool can be accessed at: http://bioinformatics.ibp.cz. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. © The Author(s) 2020. Published by Oxford University Press.

Klíčová slova

G4Killer, G-quadruplex, web application

Autoři

BRÁZDA, V.; KOLOMAZNÍK, J.; MERGNY, J.; ŠŤASTNÝ, J.

Vydáno

15. 5. 2020

ISSN

1367-4803

Periodikum

BIOINFORMATICS

Ročník

36

Číslo

10

Stát

Spojené království Velké Británie a Severního Irska

Strany od

3246

Strany do

3247

Strany počet

2

URL

https://academic.oup.com/bioinformatics/article/36/10/3246/5716328

Plný text v Digitální knihovně

http://hdl.handle.net/11012/194871

BibTex

@article{BUT164187,
  author="Václav {Brázda} and Jan {Kolomazník} and Jean-Louis {Mergny} and Jiří {Šťastný}",
  title="G4Killer web application: a tool to design G-quadruplex mutations",
  journal="BIOINFORMATICS",
  year="2020",
  volume="36",
  number="10",
  pages="3246--3247",
  doi="10.1093/bioinformatics/btaa057",
  issn="1367-4803",
  url="https://academic.oup.com/bioinformatics/article/36/10/3246/5716328"
}