Publication detail
Generation of humanized bone-marrow-like niche in immunodeficient mice
ČULEN, M. KOSAŘOVÁ, Z. SOKOL, F. CHOVANCOVÁ, J. DVOŘÁKOVÁ, D. VOJTOVÁ, L. RÁČIL, Z.
Original Title
Generation of humanized bone-marrow-like niche in immunodeficient mice
Type
conference proceedings
Language
English
Original Abstract
Imunodeficient mice represent a standard in vivo model for study of different types of human leukemias. Not all leukemic cells, however, do engraft/proliferate after xenotransplantation to mice, which is supposedly caused by inter-species differences. This problem can be resolved by introducing a humanized microenvironment into the animal recipients, via sub-cutaneous implantation of a suitable biomaterial and human mesenchymal stromal cells (MSC).
Keywords
bone-marrow, immunodeficient mice, collagen scaffold, mesenchymal stomal cells
Authors
ČULEN, M.; KOSAŘOVÁ, Z.; SOKOL, F.; CHOVANCOVÁ, J.; DVOŘÁKOVÁ, D.; VOJTOVÁ, L.; RÁČIL, Z.
Released
20. 4. 2017
Publisher
Symma s.r.o.
Location
Brno
Pages from
41
Pages to
41
Pages count
62
BibTex
@proceedings{BUT145082,
editor="Martin {Čulen} and Zdeňka {Kosařová} and Filip {Sokol} and Jana {Chovancová} and Dana {Dvořáková} and Lucy {Vojtová} and Zdeněk {Ráčil}",
title="Generation of humanized bone-marrow-like niche in immunodeficient mice",
year="2017",
pages="41--41",
publisher="Symma s.r.o.",
address="Brno"
}