Publication detail

The use of comprehensive two-dimensional gas chromatograhy with mass spectrometric detection for the assessment of drug-residue contamination of wastewater and surface water

LACINA, P. MRAVCOVÁ, L. VÁVROVÁ, M.

Original Title

The use of comprehensive two-dimensional gas chromatograhy with mass spectrometric detection for the assessment of drug-residue contamination of wastewater and surface water

Type

abstract

Language

English

Original Abstract

This study is focused on application of analytical method for analysis of selected drug residues from wastewaters and surface waters. Target compounds were acidic drugs mainly from the group of non-steroidal anti-inflammatory drugs (salicylic acid, acetylsalicylic acid, clofibric acid, ibuprofen, acetaminophen, kofein, naproxen, mefenamic acid, ketoprofen, diclofenac). Detection limits of presented method were ranged from 0.18 to 5 ng/L depending on specific compound. The method was successfully applied for determination of presence and concentration of selected drug residues in Svratka river and in wastewater from WWTP in Brno. Concentrations of drug residues were ranged from units to tens of ng/L for river water and from units to tens of ug/L for wastewaters. Analytical method used in this study includes solid phase extraction (SPE), derivatization by MSTFA (N-methyl-N-(trimethylsilyl)trifluoroacetamide) and final analysis by orthogonal comprehensive two-dimensional gas chromatography with mass spectrometric detection Time-of-Flight (GCxGC-TOF MS).

Keywords

drug residues, non-steroidal anti-inflammatory drugs, analgesics, GCxGC-TOF MS, wastewater, surface water

Authors

LACINA, P.; MRAVCOVÁ, L.; VÁVROVÁ, M.

Released

17. 8. 2011

Publisher

Fakulta chemická VUT v Brně

Location

Brno

ISBN

0009-2770

Periodical

Chemické listy

Year of study

105

State

Czech Republic

Pages from

964

Pages to

965

Pages count

2

BibTex

@misc{BUT73326,
  author="Petr {Lacina} and Ludmila {Mravcová} and Milada {Vávrová}",
  title="The use of comprehensive two-dimensional gas chromatograhy with mass spectrometric detection for the assessment of drug-residue contamination of wastewater and surface water",
  booktitle="5th Meeting on Chemistry and Life: Book of Abstracts",
  year="2011",
  journal="Chemické listy",
  volume="105",
  pages="964--965",
  publisher="Fakulta chemická VUT v Brně",
  address="Brno",
  issn="0009-2770",
  note="abstract"
}