Publication detail
On the bioprotective effects of 3-hydroxybutyrate: Thermodynamic study of binary 3HB-water systems
SLANINOVÁ, E. OBRUČA, S. KOCHERBITOV, V. SEDLÁČEK, P.
Original Title
On the bioprotective effects of 3-hydroxybutyrate: Thermodynamic study of binary 3HB-water systems
Type
journal article in Web of Science
Language
English
Original Abstract
The comprehensive study of the phase behavior of sodium 3-hydroxybutyrate (Na3HB) in aqueous mixtures has shed new light on the recently revealed bioprotective role of this compound in poly(3-hydroxybutyrate)-accumulating microorganisms. The outstandingly hydrophilic nature of 3HB is shown, which is comparable with, but in some perspectives (solubility, water activity decreased in solution) even better than some well-recognized compatible solutes such as trehalose. This is of crucial importance also from the view of its potential application in the technological fields in which stabilization of biological molecules is required (e.g., cryopreservation, food preservation, cosmetics). The study also revealed that 3HB can form, depending on the conditions, at least two different crystalline forms: anhydrous crystal and crystalline dihydrates.
Keywords
3-hydroxybutyrate;cryoprotectant;binary phase diagram;Na3HB/water system
Authors
SLANINOVÁ, E.; OBRUČA, S.; KOCHERBITOV, V.; SEDLÁČEK, P.
Released
7. 2. 2023
Publisher
Biophysical Society
ISBN
0006-3495
Periodical
BIOPHYSICAL JOURNAL
Year of study
122
Number
3
State
United States of America
Pages from
460
Pages to
469
Pages count
10
URL
Full text in the Digital Library
BibTex
@article{BUT182919,
author="Eva {Slaninová} and Stanislav {Obruča} and Vitaly {Kocherbitov} and Petr {Sedláček}",
title="On the bioprotective effects of 3-hydroxybutyrate: Thermodynamic study of binary 3HB-water systems",
journal="BIOPHYSICAL JOURNAL",
year="2023",
volume="122",
number="3",
pages="460--469",
doi="10.1016/j.bpj.2023.01.004",
issn="0006-3495",
url="https://www.sciencedirect.com/science/article/pii/S0006349523000048"
}