Detail publikace

On the bioprotective effects of 3-hydroxybutyrate: Thermodynamic study of binary 3HB-water systems

SLANINOVÁ, E. OBRUČA, S. KOCHERBITOV, V. SEDLÁČEK, P.

Originální název

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The comprehensive study of the phase behavior of sodium 3-hydroxybutyrate (Na3HB) in aqueous mixtures has shed new light on the recently revealed bioprotective role of this compound in poly(3-hydroxybutyrate)-accumulating microorganisms. The outstandingly hydrophilic nature of 3HB is shown, which is comparable with, but in some perspectives (solubility, water activity decreased in solution) even better than some well-recognized compatible solutes such as trehalose. This is of crucial importance also from the view of its potential application in the technological fields in which stabilization of biological molecules is required (e.g., cryopreservation, food preservation, cosmetics). The study also revealed that 3HB can form, depending on the conditions, at least two different crystalline forms: anhydrous crystal and crystalline dihydrates.

Klíčová slova

3-hydroxybutyrate;cryoprotectant;binary phase diagram;Na3HB/water system

Autoři

SLANINOVÁ, E.; OBRUČA, S.; KOCHERBITOV, V.; SEDLÁČEK, P.

Vydáno

7. 2. 2023

Nakladatel

Biophysical Society

ISSN

0006-3495

Periodikum

BIOPHYSICAL JOURNAL

Ročník

122

Číslo

Stát

Spojené státy americké

Strany od

460

Strany do

469

Strany počet

URL

https://www.sciencedirect.com/science/article/pii/S0006349523000048

Plný text v Digitální knihovně

http://hdl.handle.net/11012/209157

BibTex

@article{BUT182919,
  author="Eva {Slaninová} and Stanislav {Obruča} and Vitaly {Kocherbitov} and Petr {Sedláček}",
  title="On the bioprotective effects of 3-hydroxybutyrate: Thermodynamic study of binary 3HB-water systems",
  journal="BIOPHYSICAL JOURNAL",
  year="2023",
  volume="122",
  number="3",
  pages="460--469",
  doi="10.1016/j.bpj.2023.01.004",
  issn="0006-3495",
  url="https://www.sciencedirect.com/science/article/pii/S0006349523000048"
}