Publication detail

Mechanistic Impact of Zinc Deficiency in Human Development

HUSSAIN, A. JIANG, W. WANG, X. SHAHID, S. SABA, N. AHMAD, M. DAR, A. MASOOD, S U. IMRAN, M. MUSTAFA, A.

Original Title

Mechanistic Impact of Zinc Deficiency in Human Development

Type

journal article in Web of Science

Language

English

Original Abstract

Zinc (Zn) deficiency in humans is an emerging global health issue affecting approximately two billion people across the globe. The situation prevails due to the intake of Zn deficient grains and vegetables worldwide. Clinical identification of Zn deficiency in humans remains problematic because the symptoms do not appear until impair the vital organs, such as the gastrointestinal track, central nervous system, immune system, skeletal, and nervous system. Lower Zn body levels are also responsible for multiple physiological disorders, such as apoptosis, organs destruction, DNA injuries, and oxidative damage to the cellular components through reactive oxygen species (ROS). The oxidative damage causes chronic inflammation lead toward several chronic diseases, such as heart diseases, cancers, alcohol-related malady, muscular contraction, and neuro-pathogenesis. The present review focused on the physiological and growth-related changes in humans under Zn deficient conditions, mechanisms adopted by the human body under Zn deficiency for the proper functioning of the body systems, and the importance of nutritional and nutraceutical approaches to overcome Zn deficiency in humans and concluded that the biofortified food is the best source of Zn as compared to the chemical supplementation to avoid their negative impacts on human.

Keywords

Zn deficiency; detoxification; apoptosis; deoxyribonucleic acid; reactive oxygen species

Authors

HUSSAIN, A.; JIANG, W.; WANG, X.; SHAHID, S.; SABA, N.; AHMAD, M.; DAR, A.; MASOOD, S U.; IMRAN, M.; MUSTAFA, A.

Released

9. 3. 2022

Publisher

FRONTIERS MEDIA SA

Location

LAUSANNE

ISBN

2296-861X

Periodical

Frontiers in Nutrition

Year of study

9

Number

9

State

Swiss Confederation

Pages from

1

Pages to

11

Pages count

11

URL

https://www.frontiersin.org/articles/10.3389/fnut.2022.717064/full

BibTex

@article{BUT180788,
  author="HUSSAIN, A. and JIANG, W. and WANG, X. and SHAHID, S. and SABA, N. and AHMAD, M. and DAR, A. and MASOOD, S U. and IMRAN, M. and MUSTAFA, A.",
  title="Mechanistic Impact of Zinc Deficiency in Human Development",
  journal="Frontiers in Nutrition",
  year="2022",
  volume="9",
  number="9",
  pages="1--11",
  doi="10.3389/fnut.2022.717064",
  issn="2296-861X",
  url="https://www.frontiersin.org/articles/10.3389/fnut.2022.717064/full"
}