Detail publikace

Mechanistic Impact of Zinc Deficiency in Human Development

HUSSAIN, A. JIANG, W. WANG, X. SHAHID, S. SABA, N. AHMAD, M. DAR, A. MASOOD, S U. IMRAN, M. MUSTAFA, A.

Originální název

Mechanistic Impact of Zinc Deficiency in Human Development

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Zinc (Zn) deficiency in humans is an emerging global health issue affecting approximately two billion people across the globe. The situation prevails due to the intake of Zn deficient grains and vegetables worldwide. Clinical identification of Zn deficiency in humans remains problematic because the symptoms do not appear until impair the vital organs, such as the gastrointestinal track, central nervous system, immune system, skeletal, and nervous system. Lower Zn body levels are also responsible for multiple physiological disorders, such as apoptosis, organs destruction, DNA injuries, and oxidative damage to the cellular components through reactive oxygen species (ROS). The oxidative damage causes chronic inflammation lead toward several chronic diseases, such as heart diseases, cancers, alcohol-related malady, muscular contraction, and neuro-pathogenesis. The present review focused on the physiological and growth-related changes in humans under Zn deficient conditions, mechanisms adopted by the human body under Zn deficiency for the proper functioning of the body systems, and the importance of nutritional and nutraceutical approaches to overcome Zn deficiency in humans and concluded that the biofortified food is the best source of Zn as compared to the chemical supplementation to avoid their negative impacts on human.

Klíčová slova

Zn deficiency; detoxification; apoptosis; deoxyribonucleic acid; reactive oxygen species

Autoři

HUSSAIN, A.; JIANG, W.; WANG, X.; SHAHID, S.; SABA, N.; AHMAD, M.; DAR, A.; MASOOD, S U.; IMRAN, M.; MUSTAFA, A.

Vydáno

9. 3. 2022

Nakladatel

FRONTIERS MEDIA SA

Místo

LAUSANNE

ISSN

2296-861X

Periodikum

Frontiers in Nutrition

Ročník

9

Číslo

9

Stát

Švýcarská konfederace

Strany od

1

Strany do

11

Strany počet

11

URL

https://www.frontiersin.org/articles/10.3389/fnut.2022.717064/full

BibTex

@article{BUT180788,
  author="HUSSAIN, A. and JIANG, W. and WANG, X. and SHAHID, S. and SABA, N. and AHMAD, M. and DAR, A. and MASOOD, S U. and IMRAN, M. and MUSTAFA, A.",
  title="Mechanistic Impact of Zinc Deficiency in Human Development",
  journal="Frontiers in Nutrition",
  year="2022",
  volume="9",
  number="9",
  pages="1--11",
  doi="10.3389/fnut.2022.717064",
  issn="2296-861X",
  url="https://www.frontiersin.org/articles/10.3389/fnut.2022.717064/full"
}