Publication detail
Femoral bone defect healing using two novel biocompatible degradable materials
SRNEC, R. NEČASOVÁ, A. PROKS, P. SKORIC, M. FILIPEJOVÁ, Z. VOJTOVÁ, L. NEČAS, A.
Original Title
Femoral bone defect healing using two novel biocompatible degradable materials
Type
journal article in Web of Science
Language
English
Original Abstract
This study was conducted as an in vivo experiment in adult miniature pigs with the aim to test two new biomaterials. An iatrogenic defect was made into the central femoral diaphysis in the experimental animals and subsequently fixated by bridging plate osteosynthesis. Into the defect we implanted a cancellous autograft (control group), a pasty injectable scaffold (EXP A), anda porous 3D cylinder (EXP B). Radiological examination was performed in all animals at 0, 10, 20, 30 weeks after surgical procedure and histological assessment was performed. In the newly formed bone the osteoblastic activity was monitored. In terms of radiology, the most effective method was observed in the control group (completely healed 100%) compared to experimental groups EXP A (70.0%) and EXP B (62.5%).
Keywords
Pig, biomaterial, scaffold, animal model, composite, phosphate
Authors
SRNEC, R.; NEČASOVÁ, A.; PROKS, P.; SKORIC, M.; FILIPEJOVÁ, Z.; VOJTOVÁ, L.; NEČAS, A.
Released
26. 5. 2020
Publisher
Acta Veterinaria Brno
Location
Brno
ISBN
1801-7576
Periodical
ACTA VETERINARIA BRNO
Year of study
89
Number
2
State
Czech Republic
Pages from
163
Pages to
169
Pages count
7
URL
Full text in the Digital Library
BibTex
@article{BUT166347,
author="Robert {Srnec} and Andrea {Nečasová} and Pavel {Proks} and Misa {Skoric} and Zita {Filipejová} and Lucy {Vojtová} and Alois {Nečas}",
title="Femoral bone defect healing using two novel biocompatible degradable materials",
journal="ACTA VETERINARIA BRNO",
year="2020",
volume="89",
number="2",
pages="163--169",
doi="10.2754/avb202089020163",
issn="1801-7576",
url="https://actavet.vfu.cz/89/2/0163/"
}Documents