Publication detail
FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends
MELČOVÁ, V. CHALOUPKOVÁ, K. MENČÍK, P. KONTÁROVÁ, S. RAMPICHOVÁ, M. HEDVIČÁKOVÁ, V. SOVKOVÁ, V. PŘIKRYL, R. VOJTOVÁ, L.
Original Title
FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends
Type
journal article in Web of Science
Language
English
Original Abstract
Tissue engineering is a current trend in the regenerative medicine putting pressure on scientists to develop highly functional materials and methods for scaffolds’ preparation. In this paper, the calibrated filaments for Fused Deposition Modeling (FDM) based on plasticized poly(3-hydroxybutyrate)/poly(d,l-lactide) 70/30 blend modified with tricalcium phosphate bioceramics were prepared. Two different plasticizers, Citroflex (n-Butyryl tri-n-hexyl citrate) and Syncroflex (oligomeric adipate ester), both used in the amount of 12 wt%, were compared. The printing parameters for these materials were optimized and the printability was evaluated by recently published warping test. The samples were studied with respect to their thermal and mechanical properties, followed by biological in vitro tests including proliferation, viability, and osteogenic differentiation of human mesenchymal stem cells. According to the results from differential scanning calorimetry and tensile measurements, the Citroflex-based plasticizer showed very good softening effect at the expense of worse printability and unsatisfactory performance during biological testing. On the other hand, the samples with Syncroflex demonstrated lower warping tendency compared to commercial polylactide filament with the warping coefficient one third lower. Moreover, the Syncroflex-based samples exhibited the non-cytotoxicity and promising biocompatibility.
Keywords
additive manufacturing; fused deposition modeling; poly(3-hydroxybutyrate); polylactide; tricalcium phosphate; regenerative medicine; tissue engineering; bone scaffolds
Authors
MELČOVÁ, V.; CHALOUPKOVÁ, K.; MENČÍK, P.; KONTÁROVÁ, S.; RAMPICHOVÁ, M.; HEDVIČÁKOVÁ, V.; SOVKOVÁ, V.; PŘIKRYL, R.; VOJTOVÁ, L.
Released
27. 11. 2020
Publisher
MDPI
Location
Basel
ISBN
2073-4360
Periodical
Polymers
Year of study
12
Number
12
State
Swiss Confederation
Pages from
1
Pages to
19
Pages count
19
URL
Full text in the Digital Library
BibTex
@article{BUT166290,
author="Veronika {Melčová} and Kateřina {Chaloupková} and Přemysl {Menčík} and Soňa {Kontárová} and Michaela {Rampichová} and Věra {Hedvičáková} and Věra {Sovková} and Radek {Přikryl} and Lucy {Vojtová}",
title="FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends",
journal="Polymers",
year="2020",
volume="12",
number="12",
pages="1--19",
doi="10.3390/polym12122806",
issn="2073-4360",
url="https://www.mdpi.com/2073-4360/12/12/2806"
}Documents