Detail publikace
FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends
MELČOVÁ, V. CHALOUPKOVÁ, K. MENČÍK, P. KONTÁROVÁ, S. RAMPICHOVÁ, M. HEDVIČÁKOVÁ, V. SOVKOVÁ, V. PŘIKRYL, R. VOJTOVÁ, L.
Originální název
FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Tissue engineering is a current trend in the regenerative medicine putting pressure on scientists to develop highly functional materials and methods for scaffolds’ preparation. In this paper, the calibrated filaments for Fused Deposition Modeling (FDM) based on plasticized poly(3-hydroxybutyrate)/poly(d,l-lactide) 70/30 blend modified with tricalcium phosphate bioceramics were prepared. Two different plasticizers, Citroflex (n-Butyryl tri-n-hexyl citrate) and Syncroflex (oligomeric adipate ester), both used in the amount of 12 wt%, were compared. The printing parameters for these materials were optimized and the printability was evaluated by recently published warping test. The samples were studied with respect to their thermal and mechanical properties, followed by biological in vitro tests including proliferation, viability, and osteogenic differentiation of human mesenchymal stem cells. According to the results from differential scanning calorimetry and tensile measurements, the Citroflex-based plasticizer showed very good softening effect at the expense of worse printability and unsatisfactory performance during biological testing. On the other hand, the samples with Syncroflex demonstrated lower warping tendency compared to commercial polylactide filament with the warping coefficient one third lower. Moreover, the Syncroflex-based samples exhibited the non-cytotoxicity and promising biocompatibility.
Klíčová slova
additive manufacturing; fused deposition modeling; poly(3-hydroxybutyrate); polylactide; tricalcium phosphate; regenerative medicine; tissue engineering; bone scaffolds
Autoři
MELČOVÁ, V.; CHALOUPKOVÁ, K.; MENČÍK, P.; KONTÁROVÁ, S.; RAMPICHOVÁ, M.; HEDVIČÁKOVÁ, V.; SOVKOVÁ, V.; PŘIKRYL, R.; VOJTOVÁ, L.
Vydáno
27. 11. 2020
Nakladatel
MDPI
Místo
Basel
ISSN
2073-4360
Periodikum
Polymers
Ročník
12
Číslo
12
Stát
Švýcarská konfederace
Strany od
1
Strany do
19
Strany počet
19
URL
Plný text v Digitální knihovně
BibTex
@article{BUT166290,
author="Veronika {Melčová} and Kateřina {Chaloupková} and Přemysl {Menčík} and Soňa {Kontárová} and Michaela {Rampichová} and Věra {Hedvičáková} and Věra {Sovková} and Radek {Přikryl} and Lucy {Vojtová}",
title="FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends",
journal="Polymers",
year="2020",
volume="12",
number="12",
pages="1--19",
doi="10.3390/polym12122806",
issn="2073-4360",
url="https://www.mdpi.com/2073-4360/12/12/2806"
}Dokumenty