Publication detail

Micellar nanocarriers based on hydrophobical hyaluronan

VELCER, T. PEKAŘ, M.

Original Title

Type

abstract

Language

English

Original Abstract

This work studies the properties of modified biopolymers for potential use in targeted drug delivery. Various samples of hydrophobically modified hyaluronan with different degree of substitution were selected. The critical aggregation concentration (CAC) of these samples was measured using fluorescence spectroscopy, wherein it was found that micelle formation occurs over a wide concentration region. Environment of 0.15 M NaCl causes the decrease of CAC only slightly or not at all. The results were confirmed by measuring the dynamic light scattering, which also showed an increase in the size of aggregates with an increasing concentration. One of the samples exhibited a double size distribution. Zeta potential measurements provide information about stability of the samples. The results of this study confirm that the studied samples seem to be a suitable candidates for the post of drug carrier for targeted delivery.

Keywords

hydrophobically modified hyaluronan, fluorescence spectroscopy, dynamic light scattering

Authors

VELCER, T.; PEKAŘ, M.

Released

16. 10. 2019

Publisher

TANGER Ltd.

Location

Ostrava, CZ

ISBN

978-80-87294-94-9

Book

NANOCON 2019 - Abstracts

Edition

Pages from

123

Pages to

123

Pages count

BibTex

@misc{BUT165641,
  author="Tomáš {Velcer} and Miloslav {Pekař}",
  title="Micellar nanocarriers based on hydrophobical hyaluronan",
  booktitle="NANOCON 2019 - Abstracts",
  year="2019",
  series="1.",
  pages="123--123",
  publisher="TANGER Ltd.",
  address="Ostrava, CZ",
  isbn="978-80-87294-94-9",
  note="abstract"
}