Detail publikace

Micellar nanocarriers based on hydrophobical hyaluronan

VELCER, T. PEKAŘ, M.

Originální název

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

This work studies the properties of modified biopolymers for potential use in targeted drug delivery. Various samples of hydrophobically modified hyaluronan with different degree of substitution were selected. The critical aggregation concentration (CAC) of these samples was measured using fluorescence spectroscopy, wherein it was found that micelle formation occurs over a wide concentration region. Environment of 0.15 M NaCl causes the decrease of CAC only slightly or not at all. The results were confirmed by measuring the dynamic light scattering, which also showed an increase in the size of aggregates with an increasing concentration. One of the samples exhibited a double size distribution. Zeta potential measurements provide information about stability of the samples. The results of this study confirm that the studied samples seem to be a suitable candidates for the post of drug carrier for targeted delivery.

Klíčová slova

hydrophobically modified hyaluronan, fluorescence spectroscopy, dynamic light scattering

Autoři

VELCER, T.; PEKAŘ, M.

Vydáno

16. 10. 2019

Nakladatel

TANGER Ltd.

Místo

Ostrava, CZ

ISBN

978-80-87294-94-9

Kniha

NANOCON 2019 - Abstracts

Edice

Strany od

123

Strany do

123

Strany počet

BibTex

@misc{BUT165641,
  author="Tomáš {Velcer} and Miloslav {Pekař}",
  title="Micellar nanocarriers based on hydrophobical hyaluronan",
  booktitle="NANOCON 2019 - Abstracts",
  year="2019",
  series="1.",
  pages="123--123",
  publisher="TANGER Ltd.",
  address="Ostrava, CZ",
  isbn="978-80-87294-94-9",
  note="abstract"
}