Publication detail

Attenuation of p53-alpha isoform transactivation by inverted repeat sequernces in p53 target sites

BRÁZDA, V. PORUBIAKOVÁ, O. BOHÁLOVÁ, N. INGA, A. FOJTA, M.

Original Title

Type

abstract

Language

English

Original Abstract

p53 is one of the most studied tumour suppressor proteins, playing important roles in regulation basic biological processes. p53 function is realized by binding to specific DNA response elements resulting in the transactivation of target genes. Here we present results of p53 alpha isoform obtained using a yeast isogenic system for in vivo transactivation studies in chromosomal context to specifically evaluate the influence of secondary DNA structures on transactivation.

Keywords

p53-alpha, p53-alpha isoforms, inverted repeats, p53 target sites

Authors

BRÁZDA, V.; PORUBIAKOVÁ, O.; BOHÁLOVÁ, N.; INGA, A.; FOJTA, M.

Released

6. 7. 2019

Pages from

Pages to

Pages count

BibTex

@misc{BUT157761,
  author="Václav {Brázda} and Otília {Porubiaková} and Natália {Bohálová} and Alberto {Inga} and Miroslav {Fojta}",
  title="Attenuation of p53-alpha isoform transactivation by inverted repeat sequernces in p53 target sites",
  year="2019",
  pages="1--1",
  note="abstract"
}