Detail publikace

Attenuation of p53-alpha isoform transactivation by inverted repeat sequernces in p53 target sites

BRÁZDA, V. PORUBIAKOVÁ, O. BOHÁLOVÁ, N. INGA, A. FOJTA, M.

Originální název

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

p53 is one of the most studied tumour suppressor proteins, playing important roles in regulation basic biological processes. p53 function is realized by binding to specific DNA response elements resulting in the transactivation of target genes. Here we present results of p53 alpha isoform obtained using a yeast isogenic system for in vivo transactivation studies in chromosomal context to specifically evaluate the influence of secondary DNA structures on transactivation.

Klíčová slova

p53-alpha, p53-alpha isoforms, inverted repeats, p53 target sites

Autoři

BRÁZDA, V.; PORUBIAKOVÁ, O.; BOHÁLOVÁ, N.; INGA, A.; FOJTA, M.

Vydáno

6. 7. 2019

Strany od

Strany do

Strany počet

BibTex

@misc{BUT157761,
  author="Václav {Brázda} and Otília {Porubiaková} and Natália {Bohálová} and Alberto {Inga} and Miroslav {Fojta}",
  title="Attenuation of p53-alpha isoform transactivation by inverted repeat sequernces in p53 target sites",
  year="2019",
  pages="1--1",
  note="abstract"
}