Publication detail

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

KOVÁŘ, D. HUBÁLEK, J. FOHLEROVÁ, Z. MALÁ, A. KALINA, M. JIŘÍK, R. STARČUK, Z. SKLÁDAL, P. HLAVÁČEK, A.

Original Title

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Type

journal article in Web of Science

Language

English

Original Abstract

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities and ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising -contrast probe.

Keywords

magnetic nanoparticles, MRI imaging

Authors

KOVÁŘ, D.; HUBÁLEK, J.; FOHLEROVÁ, Z.; MALÁ, A.; KALINA, M.; JIŘÍK, R.; STARČUK, Z.; SKLÁDAL, P.; HLAVÁČEK, A.

Released

23. 2. 2017

Publisher

Hindawi Publishing Corporation

ISBN

1687-4110

Periodical

JOURNAL OF NANOMATERIALS

Year of study

2017

Number

1

State

United States of America

Pages from

1

Pages to

8

Pages count

8

URL

http://dx.doi.org/10.1155/2017/7859289

Full text in the Digital Library

http://hdl.handle.net/11012/68359

BibTex

@article{BUT134091,
  author="David {Kovář} and Jaromír {Hubálek} and Zdenka {Fohlerová} and Aneta {Malá} and Michal {Kalina} and Radovan {Jiřík} and Antonín {Hlaváček} and Ondřej {Slabý} and Petr {Skládal} and Zdeněk {Farka} and Jitka {Mlčochová} and Zenon {Starčuk jr.}",
  title="Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging",
  journal="JOURNAL OF NANOMATERIALS",
  year="2017",
  volume="2017",
  number="1",
  pages="1--8",
  doi="10.1155/2017/7859289",
  issn="1687-4110",
  url="http://dx.doi.org/10.1155/2017/7859289"
}