Detail publikace

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

KOVÁŘ, D. HUBÁLEK, J. FOHLEROVÁ, Z. MALÁ, A. KALINA, M. JIŘÍK, R. STARČUK, Z. SKLÁDAL, P. HLAVÁČEK, A.

Originální název

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities and ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising -contrast probe.

Klíčová slova

magnetic nanoparticles, MRI imaging

Autoři

KOVÁŘ, D.; HUBÁLEK, J.; FOHLEROVÁ, Z.; MALÁ, A.; KALINA, M.; JIŘÍK, R.; STARČUK, Z.; SKLÁDAL, P.; HLAVÁČEK, A.

Vydáno

23. 2. 2017

Nakladatel

Hindawi Publishing Corporation

ISSN

1687-4110

Periodikum

JOURNAL OF NANOMATERIALS

Ročník

2017

Číslo

1

Stát

Spojené státy americké

Strany od

1

Strany do

8

Strany počet

8

URL

http://dx.doi.org/10.1155/2017/7859289

Plný text v Digitální knihovně

http://hdl.handle.net/11012/68359

BibTex

@article{BUT134091,
  author="David {Kovář} and Jaromír {Hubálek} and Zdenka {Fohlerová} and Aneta {Malá} and Michal {Kalina} and Radovan {Jiřík} and Antonín {Hlaváček} and Ondřej {Slabý} and Petr {Skládal} and Zdeněk {Farka} and Jitka {Mlčochová} and Zenon {Starčuk jr.}",
  title="Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging",
  journal="JOURNAL OF NANOMATERIALS",
  year="2017",
  volume="2017",
  number="1",
  pages="1--8",
  doi="10.1155/2017/7859289",
  issn="1687-4110",
  url="http://dx.doi.org/10.1155/2017/7859289"
}