Publication detail
Study of the glass transition of co-amorphous drug by DMA
TÜRKEOVÁ, I. SOLNÝ, T. KLUČÁKOVÁ, M.
Original Title
Study of the glass transition of co-amorphous drug by DMA
Type
conference paper
Language
English
Original Abstract
Nowadays in pharmaceutical research is problem that new chemical entities are poorly water soluble and therefore present a low dissolution rate. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. In this study, the co-amorphous IND-TRY mixtures were prepared by mechanical activation – ball milling. It was given different amount of polyvinylpyrrolidon to the mixture and was characterized. Solid - state properties were analyzed by dynamic mechanical analysis (DMA). It was found that addition of polyvinylpyrrolidon improved stability compared to the pure co-amorphous form. Glass transition state is growing with addition of PVP.
Keywords
co-amorphous system, dynamic mechanical analysis, solubility drugs
Authors
TÜRKEOVÁ, I.; SOLNÝ, T.; KLUČÁKOVÁ, M.
Released
6. 6. 2016
Publisher
MUNI press
Location
Masaryk University, Brno, Czech Republic
ISBN
978-80-210-8267-0
Book
XVI. Workshop of physical chemists and electrochemists Book of abstracts
Edition
1
Pages from
212
Pages to
214
Pages count
3
BibTex
@inproceedings{BUT129225,
author="Irena {Solná} and Tomáš {Solný} and Martina {Klučáková}",
title="Study of the glass transition of co-amorphous drug by DMA
",
booktitle="XVI. Workshop of physical chemists and electrochemists Book of abstracts",
year="2016",
series="1",
pages="212--214",
publisher="MUNI press",
address="Masaryk University, Brno, Czech Republic",
isbn="978-80-210-8267-0"
}