Detail publikace

Study of the glass transition of co-amorphous drug by DMA

TÜRKEOVÁ, I. SOLNÝ, T. KLUČÁKOVÁ, M.

Originální název

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

Nowadays in pharmaceutical research is problem that new chemical entities are poorly water soluble and therefore present a low dissolution rate. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. In this study, the co-amorphous IND-TRY mixtures were prepared by mechanical activation – ball milling. It was given different amount of polyvinylpyrrolidon to the mixture and was characterized. Solid - state properties were analyzed by dynamic mechanical analysis (DMA). It was found that addition of polyvinylpyrrolidon improved stability compared to the pure co-amorphous form. Glass transition state is growing with addition of PVP.

Klíčová slova

co-amorphous system, dynamic mechanical analysis, solubility drugs

Autoři

TÜRKEOVÁ, I.; SOLNÝ, T.; KLUČÁKOVÁ, M.

Vydáno

6. 6. 2016

Nakladatel

MUNI press

Místo

Masaryk University, Brno, Czech Republic

ISBN

978-80-210-8267-0

Kniha

XVI. Workshop of physical chemists and electrochemists Book of abstracts

Edice

Strany od

212

Strany do

214

Strany počet

BibTex

@inproceedings{BUT129225,
  author="Irena {Solná} and Tomáš {Solný} and Martina {Klučáková}",
  title="Study of the glass transition of co-amorphous drug by DMA
",
  booktitle="XVI. Workshop of physical chemists and electrochemists Book of abstracts",
  year="2016",
  series="1",
  pages="212--214",
  publisher="MUNI press",
  address="Masaryk University, Brno, Czech Republic",
  isbn="978-80-210-8267-0"
}