Publication detail

Study on Mutual Interactions and Electronic Structures of Hyaluronan with Lysine, 6-Aminocaproic Acid and Arginine

Chytil M , Trojan M , Kovalenko A

Original Title

Study on Mutual Interactions and Electronic Structures of Hyaluronan with Lysine, 6-Aminocaproic Acid and Arginine

Type

journal article in Web of Science

Language

English

Original Abstract

Interactions between polyelectrolytes and oppositely charged surfactants have been in a great interest for several decades, yet the conventional surfactants may cause a problem in medical applications. Interactivity between polysaccharide hyaluronan (HA) and amino acids Lysine, 6-Aminocaproic acid (6-AcA), and Arginine as an alternative system is reported. The interactions were investigated by means of rheology and electric conductance and the electronic structures were explored by the density functional theory (DFT). Lysine exhibits the strongest interaction of all, which was manifested, e.g. by nearly 6-time drop of the initial viscosity comparing with only 1.3-time lower value in the case of 6-AcA. Arginine interaction with HA was surprisingly weaker in terms of viscosity than that of Lysine due to a lower and delocalized charge density on its guanidine group. According to the DFT calculations, the binding of Lysine to HA was found to be more flexible, while Arginine creates more rigid structure with HA.

Keywords

hyaluronan, amino acids, interactions, rheology, density functional theory (DFT)

Authors

Chytil M , Trojan M , Kovalenko A

Released

20. 5. 2016

Publisher

Elsevier

ISBN

0144-8617

Periodical

Carbohydrate Polymers

Year of study

142

State

United Kingdom of Great Britain and Northern Ireland

Pages from

8

Pages to

15

Pages count

8

URL

http://www.sciencedirect.com/science/article/pii/S0144861716000503

BibTex

@article{BUT126482,
  author="Alexander {Kovalenko}",
  title="Study on Mutual Interactions and Electronic Structures of Hyaluronan with Lysine, 6-Aminocaproic Acid and Arginine",
  journal="Carbohydrate Polymers",
  year="2016",
  volume="142",
  number="0",
  pages="8--15",
  doi="10.1016/j.carbpol.2016.01.035",
  issn="0144-8617",
  url="http://www.sciencedirect.com/science/article/pii/S0144861716000503"
}