Publication detail

Selenium containing heterocyclic: Synthesis, antimicrobial of some new selenazole Substituted phthalazin-ones

EL-SHAMY, I. ABDEL-LATTIF, A. FOUDA, M. ALMONASY, N. AL-DEYAB, S. EL-HASHASH, M.

Original Title

Type

journal article - other

Language

English

Original Abstract

The principal purpose of the present study is to synthesize and investigate the antimicrobial and antifungal activities of new 1, 3-selenazole derivatives having phthalazin-1(2H)-one moieties. A multi-step reaction route was developed to synthesize a several of targeted derivatives starting from 4-alkyl/aryl-phthalazin-1(2H)-one and 2-chloro-N-phenylacetamide. The structures of the synthesized compounds were confirmed by 1HNMR, 13CNMR, MS, IR spectroscopy and by elemental analysis. The antimicrobial and antifungal activities of all derivatives against four species of bacteria and two species of fungi were investigated. The antimicrobial and antifungal activity was determined in the extracts using disk diffusion method. Amoxicillin and Ketoconazole were used as standard drugs for the bacteria and fungi, respectively.

Keywords

Selenium, phthalazin-1(2H)-one, antimicrobial activity

Authors

EL-SHAMY, I.; ABDEL-LATTIF, A.; FOUDA, M.; ALMONASY, N.; AL-DEYAB, S.; EL-HASHASH, M.

RIV year

2013

Released

18. 10. 2013

ISBN

1097-8135

Periodical

Life Science Journal

Year of study

Number

State

People's Republic of China

Pages from

799

Pages to

809

Pages count

BibTex

@article{BUT106135,
  author="Ibrahim E. {El-Shamy} and Abdelmohsen Moustafa {Abdellatif} and Moustafa M.D. {Fouda} and Numan {Almonasy} and Salem S. {Al-Deyab} and Maher A. {El-Hashash}",
  title="Selenium containing heterocyclic: Synthesis, antimicrobial of some new selenazole Substituted phthalazin-ones",
  journal="Life Science Journal",
  year="2013",
  volume="10",
  number="4",
  pages="799--809",
  issn="1097-8135"
}