In this project, a fully bioresorbable 3D printed scaffold will be enriched with liposomal antibacterial enzyme Lysostaphin to promote the bone healing process and prevent a bone infection osteomyelitis caused by Staphylococcus aureus. The material for scaffold printing will be based on thermosensitive copolymer, chitosan, and calcium phosphate and will be enriched with liposomal Lysostaphin in two different approaches. The scaffolds will be characterized, and lysostaphin release and antibacterial properties of such material will be evaluated.

CEITEC VUT-J-22-8079

Czech

Kadlecová Zuzana, Ing. - principal person responsible
Vojtová Lucy, doc. Ing., Ph.D. - fellow researcher

Advanced Biomaterials
- responsible department (3.3.2022 - not assigned)
Central European Institute of Technology BUT
- responsible department (13.2.2022 - 3.3.2022)
Advanced Biomaterials
- internal (1.1.2022 - 31.12.2022)
Central European Institute of Technology BUT
- beneficiary (1.1.2022 - 31.12.2022)

KADLECOVÁ, Z.; LYSÁKOVÁ, K.; HLINÁKOVÁ, K.; MENČÍK, P.; VOJTOVÁ, L. Enhancing protein release from bone scaffolds via encapsulation into either liposomes or polymersomes. Bioimplantologie a regenerativní medicína 2024. 1. Praha: České vysoké učení technické v Praze, 2024. p. 37-37. ISBN: 978-80-01-07293-6.
Detail

KADLECOVÁ, Z.; LYSÁKOVÁ, K.; VOJTOVÁ, L. 3D printed Calcium Phosphate Cements enriched with liposome-encapsulated antibacterial enzymes for bone infection treatment. Czech Chemical Society Symposium Series. Czech Chemical Society, 2023. p. 88-88. ISSN: 2336-7210.
Detail

KADLECOVÁ, Z.; HLINÁKOVÁ, K.; VOJTOVÁ, L. 3D Printed calcium phosphate cement scaffolds loaded with liposomal antibacterial enzymes for the prevention of osteomyelitis. Program and Book of Abstracts TWENTY-THIRD ANNUAL CONFERENCE YUCOMAT 2022 & TWELFTH WORLD ROUND TABLE CONFERENCE ON SINTERING XII WRTCS. 1. Belgrade: Materials Research Society of Serbia, 2022. p. 98-98. ISBN: 978-86-919111-7-1.
Detail

Responsibility: Kadlecová Zuzana, Ing.