Publication detail

3D printed Calcium Phosphate Cements enriched with liposome-encapsulated antibacterial enzymes for bone infection treatment

KADLECOVÁ, Z. LYSÁKOVÁ, K. VOJTOVÁ, L.

Original Title

3D printed Calcium Phosphate Cements enriched with liposome-encapsulated antibacterial enzymes for bone infection treatment

Type

abstract

Language

English

Original Abstract

Three-dimensional (3D) printing has been in focus in recent years. Via this method, it is possible to prepare bioactive, patient-specific porous scaffolds1. The process of p of the 3D printed scaffold is often accompanied by several microorganisms, which can lead to a bone infection known as osteomyelitis2. The combination of the thermosensitive copolymer, the calcium phosphate powder and suitable enzymes gives an ideal combination for 3D printing of bone implants with well-defined pore size, mechanical properties, degradation rate, as well as antibacterial activity. Therefore, as the scaffold resorbs, the antibacterial enzymes are released and the osteomyelitis can be suppressed. Unfortunately, as our previous study discovered, the incorporated enzymes do not release in sufficient amounts, due to the microstructure of the 3D-printed scaffold. In this project, the antibacterial enzyme lysozyme was encapsulated into liposomes, providing additional chemical and physical protection to the enzyme during the scaffold curing.

Keywords

liposomes, antibacterial, calcium phosphate cement, release, lysostaphine

Authors

KADLECOVÁ, Z.; LYSÁKOVÁ, K.; VOJTOVÁ, L.

Released

17. 4. 2023

Publisher

Czech Chemical Society

ISBN

2336-7210

Periodical

Czech Chemical Society Symposium Series

Year of study

21

Number

2

State

Czech Republic

Pages from

88

Pages to

88

Pages count

56

URL

http://www.ccsss.cz/index.php/ccsss/issue/view/38/69

BibTex

@misc{BUT183517,
  author="Zuzana {Kadlecová} and Klára {Tušlová} and Lucy {Vojtová}",
  title="3D printed Calcium Phosphate Cements enriched with liposome-encapsulated antibacterial enzymes for bone infection treatment",
  year="2023",
  journal="Czech Chemical Society Symposium Series",
  volume="21",
  number="2",
  pages="88--88",
  publisher="Czech Chemical Society",
  issn="2336-7210",
  url="http://www.ccsss.cz/index.php/ccsss/issue/view/38/69",
  note="abstract"
}