Course detail
Engineering of Chemical-Pharmaceutical Production
FCH-MC_ICHVAcad. year: 2025/2026
The course provides theoretical and practical foundations of Particular systems and Powder technology applied for the production of pharmaceuticals.
Particle systems characterization, basic parameters of particulates and the measurement of them. Grain sizing and morphology of particulates.
Conveying and handling of particulates. Comminution, separation, homogenization, segregation, compaction, aglomeration, size enlargement, drying and thermal processes of particulates.
Surface properties of fine-particle materials, sorption, surface moisture. Suspension and dispersion formation. Surface treatment of particulates. Material handling, sampling and dosing. Bulk properties of particulates. Pumping and dosing of fluids. Basis of bulk storage, hoppers and feeders design. Powder Technology project planning and the production control fundamentals. Dust nuisance. Particulates and drug production, handling operating safety.
Language of instruction
Number of ECTS credits
Mode of study
Guarantor
Entry knowledge
Rules for evaluation and completion of the course
Lectures on the most problematical points of the Powder Technology processes in the pharmaceutical industry. Permanently inovated lectures demand attending of students. Recommended literature and the main thesis of the lectures on www pages of Faculty of Chemistry is insufficient for the successfull exam.
Aims
Basic knowledge of both Powder Technology theory and practice used in today´s pharmaceutical processes.
Study aids
Prerequisites and corequisites
Basic literature
Hovorka F.: Technologie chemických výrob. VŠCHT Praha, 2012. (CS)
Recommended reading
Masuda H., Higashitani K, Yoshida H.: Powder Technology Handbook, Third Edition, CRC Press, 2006. ISBN: 978-1574447828 H. Masuda, K. Higashitani, H. Yoshida, Taylor and Francis, 2006, ISBN-13: 978-1574447828
Salman A.D., Ghadiri M., Hounslow M.J.: Handbook of Powder Technology, Volume 12, Elsevier, 2007. ISBN 978-0444530806
Classification of course in study plans
- Programme NPCP_CHMA Master's
specialization BF , 2 year of study, winter semester, compulsory-optional
specialization CHBL , 2 year of study, winter semester, compulsory-optional - Programme NPCP_CHPL Master's 2 year of study, winter semester, compulsory-optional
- Programme NKCP_CHPL Master's 2 year of study, winter semester, compulsory-optional
Type of course unit
Lecture
Teacher / Lecturer
Syllabus
2. Transportation, convaing and handling with particular systems. The issue of classification and separation .
3. The processes of disintegration, preparation of ultra-fine to nano - fine particulate systems.
4. Homogenization of powder systems, segregation, compaction, agglomeration, granulation, tabletting.
5. Drying and heat exposure of ultrafine particulate matter. Lyophilization .
6. Bulk properties of particulate systems, ways of the bulk properties measurement. Basis of bulk storage, hoppers, feeders and warehousing design.
7. Surface properties of fine-grained particulate matter , sorption properties , moisture transport and equilibrium moisture content of particulate matter.
8. Surface modification of powders. Surface treatment of solid dosage forms. Making the multi-layers systems.
9. Making suspensions and dispersions. Homogenization of liquids and pastes .
10. Sampling of particulate systems. Performance of solid dosage forms in containers , " blistering ", expedition .
11. The issue of transport, storage and dosing of liquid systems.
12. Specifics of measurement and control of chemical- pharmaceutical processes. The issue of planning , approval and implementation of new pharmaceutical processes.
13. Aspects of dust. Work safety with particular biological and chemical- active systems.
Guided consultation in combined form of studies
Teacher / Lecturer