Course detail

Construction of Medical and Biotechnological Equipment

FCH-BC_KSAcad. year: 2024/2025

Students will be briefly familiarise with materials used in process of equipment and components constructions in small productions-tonnage chemical, pharmacy, biotechnology and medical industry. The special materials manufacturing will be presented to students, as well as the material characteristics, heat treatment, connection of komponent (welding and threaded joint). The fundamentals of stess and strain calculation in the design of equipment will be presented, qualification process, calculation of wall thickness, principle of maintenance. The special specification of equipment indicated for pharmacy production will be presented.

Language of instruction

Czech

Number of ECTS credits

Mode of study

Not applicable.

Guarantor

Ing. Dušan Vincour, Ph.D.

Department

Institute of Physical and Applied Chemistry (ÚFSCH)

Entry knowledge

Basic knowledge of elasticity and strength, material science, machine components.

Rules for evaluation and completion of the course

Marked credits are awarded on the basis of written essay (including simple design calculation of wall thiskness) and oral discussion (colloquium).

Aims

The aim is to explain problems of design and construction of pressure tanks and vessels and to teach practical applications. Explanation of differences in construction of processing lines and standard constructions, especially from the point of view of safety.
Students will be oriented in calculation and design of pressure vessels and pipes using the membrain theory, they will have the basic information about special materials for pharmacy and biotchnological industry icluding some material degradation (environment affecting on materials).

Study aids

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

Bailey, J, Ollis,D.: Biochemical engineering fundamentals, McGraw-Hill, 1977 (EN)
Johnson, A. T.: Biology for engineers. CRC Press, c2011, ISBN: 978-1-4200-7763-6 (EN)
Medek, J.: Hydraulické pochody, VUT Brno FSI, 2000 (CS)
Medek, J.: Mechanické pochody, VUT Brno FSI, 1998 (CS)
Moláček, M.: Konstrukce zpracovatelských strojů, VUT Brno FSI, 1989 (CS)
Street, L. J.: Introduction to biomedical engineering technology, CRC, London : Taylor & Francis, 2008, ISBN: 0849385334 (EN)
Uherek, J.:Biotechnologické linky, VUT Brno FSI, 1988 (CS)

Type of course unit

Lecture

26 hod., optionally

Teacher / Lecturer

Ing. Dušan Vincour, Ph.D.

Syllabus

1. History of pressure vessels and apparatuses, contemporary examples. Basic technological types (vessels, apparatuses, reactors, pipelines, armatures).
2. Technical requirements on constructions – standards (selection of materials, technical, operating, safety, and reliability factors).
3. Design of technological apparatuses, basic principles (technological, strength, economical, and lifespan factors).
4. Selection of material for production units, corrosion protection and surface treatment. Production of metallurgical material, standards for its assortment.
5. Destructive material testing.
6. Overview of materials connecting (welding, pressing, screwed joints and their sealing). Welding methods, welds marking on drawings. Legislative demands on tightness.
7. Overview of weld defects. Forms of crack formation (hot, cold, lamellar, annealing). Testing of weld joints.
8. Design of wall thickness for pipelines, vessels and apparatuses under inner or external overpressure, own weight, and vibrations.
9. Degradation mechanisms on equipment (material fatigue, effect of increased
10. Evaluation of lifetime of production equipment on the basis of their design and construction, production method, degradation mechanisms and loading history.
11. Reliability of equipment, assessment of risk of failure and accident.
12. Non-destructive tests in production and during equipment operation (visual, ultrasound, radiation, capillary).
13. Operating of technological systems (control, maintenance, tests, monitoring, qualification, legislative requirements).