Course detail

Advanced Analytical Chemistry

FCH-BA_AACHAcad. year: 2024/2025

This course aims to introduct students to the modern methods and techniques of analytical chemistry. Teaching is structured in the following thematic areas: Physical aspects of analytical methods. Organic chemistry in modern analytical methods. Principles of senzors and biosenzors, their use in different areas (environmental analysis, renewable energy sources, medicine). Practical use of senzores. Modern, fast and simple use of "Lab on chip" for routine analysis. Principles and instrumental methods in imaging techniques based on mass spectrometry, their potential and practical use. The principles of modern isotopical analysis, the use in the environmental analysis,forensic analysis or medicine.

Language of instruction

English

Number of ECTS credits

Mode of study

Not applicable.

Guarantor

doc. Mgr. Michaela Vašinová Galiová, Ph.D.

Department

Institute of Chemistry and Technology of Environmental Protection (ÚCHTOŽP)

Entry knowledge

Knowledge from the course Analytical chemistry I and II, knowledge from Physics (electricity, magnetism), knowledge from Physical chemistry I and II.

Rules for evaluation and completion of the course

As part of the course evaluation, students prepare a seminar paper on a topic of their choice. On this subject will be followed by a presentation and discussion.
Attendance at lectures is recommended, but not checked. Consultations during the semester will be possible for students of the combined form of study. Consultations are also provided to full-time students on request. If will be necessary, the lectures will be organized online.

Aims

The aim of the course is to provide students with an overview of specific methods used in analytical chemistry in the field of senzors, lab on chip, izotopic analysis and imaging by mass spectrometric methods.
By completion of the course the student will gain the following knowledge and skills:

1. They will know in depth the principles of operation of sensors used in the field of environmental and forensic analysis.
2. They will know the principles of advanced analysis in the field of imaging methods using mass spectrometry and in the field of isotope analysis.
3. They will be able to imagine the functioning of analytical laboratories using the so-called lab on chip, their practical use for routine analysis.
4. They will be able to choose the optimal method for the needs of routine and automated analyzes but also very advanced analyzes in imaging techniques in different fields of analytical chemistry.

Study aids

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

Alessandra Sussulini: Metabolomics: From Fundamentals to Clinical Applications, 2017 (EN)
Miguel de la Guardia, et.al.: Handbook of Smart Materials in Analytical Chemistry, 2019 (EN)

Type of course unit

Lecture

26 hod., optionally

Teacher / Lecturer

Ing. Martin Cigánek, Ph.D.
Ing. Ludmila Mravcová, Ph.D.
Ing. Veronika Řezáčová, Ph.D.
doc. Mgr. Michaela Vašinová Galiová, Ph.D.
Mgr. Helena Doležalová Weissmannová, Ph.D.

Syllabus

Topic I : Senzores in analytical chemistry
1. Introduction to modern analytical chemistry, a look into the use of sensors in automated analysis
2. Supramolecular organic chemistry
3. Molecular interaction, electrodes
4. Nanoparticles and their use in analytical chemistry
5. Automatic sensor system for continuous analysis in different areas (energy, environment, medicine)

Topic II: Lab on chip
6. Lab on chip in chromatography and mass spectrometry
7. Lab on chip for elemental analysis
8. Lab on chip in toxikology and ekotoxicology

Topic III: Modern application in life sciences
9. Metabolomic analysis
10. Imaging techniques I
11. Imaging techniques II
12. Principles of advanced data analysis

Topic IV: Students semestral work presentation
13. Students presentation of semestral work on a selected topic related to the content of the course