Course detail
Special Toxicology
FCH-MCO_STXAcad. year: 2012/2013
Definition of dose-response relationship, toxicity, interactions of substances at different levels. Biotransformation of toxic compounds. Toxicological characteristics of elements, inorganic and organic compounds, organometallic compounds, alkaloids, biologically active substances, natural toxins of fungi, algae, plants and animals. Radiotoxicology warfare agents, pesticides. Principles of carcinogenic, mutagenic and teratogenic effects.
Language of instruction
Number of ECTS credits
Mode of study
Learning outcomes of the course unit
1st Students will be capable of application concepts in the field of special toxicology and other chemical and toxicological fields (environmental chemistry, ecotoxicology, etc.).
2nd Students will gain knowledge of mechanisms of toxic effects on organisms, students will know the different types of toxic effects, students will understand the impact factors (external and internal) on the toxicity of substances. Bbiotransformation of compounds will be explained.
3rd Students gain knowledge of toxicity of elements and their compounds, selected organic compounds, organometallic compounds, alkaloids, biologically active substances, toxins of fungi, algae, plants, animals.
4th Students gain knowledge of radiotoxicology, warfare agents, pesticides.
5th Students will understand the carcinogenic, mutagenic and teratogenic effects of compounds and toxins.
Prerequisites
Co-requisites
Planned learning activities and teaching methods
Assesment methods and criteria linked to learning outcomes
Course curriculum
2nd Toxic effects on the organ level.
3rd Biotransformation of toxic substances in the body (principle, phase, factors affecting biotransformation), biotransformation of selected compounds.
4th Toxicological characteristics of elements, inorganic and organic compounds, organometallic compounds.
5th Toxicological characteristics of alkaloids.
6th Toxicological characteristics of biologically active substances.
7th Toxicological characteristics of fungal and algal toxins, toxicologically important algae, micromycetes and macromycetes, cyanobacteria.
8th Toxicological characteristics of plant toxins, toxicologically important species of plants.
9th Toxicological characteristics of animal toxins, toxicologically important animal species.
10th Radiotoxicology.
11th Toxicology of warfare agents, pesticides.
12th Principles of carcinogenic, mutagenic and teratogenic effects. Inhibitors, inducers of natural and synthetic mutagens, carcinogens, teratogens.
Work placements
Aims
Specification of controlled education, way of implementation and compensation for absences
An integral part of teaching and combined form of teaching is a e-learning tutorial course, divided into blocks, within which are available to students learning support including electronic textbooks, presentations, lectures, and other complementary materials.
For students in combined form of study are organized consultations on the topics for full-time students.
Consultations are also provided to full-time students on request.
Recommended optional programme components
Prerequisites and corequisites
Basic literature
Hodgson, E., Levi P. E., A Textbook of Modern Toxicology, Elsevier Sci. Publ., New York, Amsterdam, London, 1987 (CS)
Lindsay Murray, Frank Daly, Mike Cadogan , Toxicology Handbook, 2011, Elsevier (CS)
Tichý, M., Toxikologie pro chemiky. Universita Karlova, Praha, 2002 (CS)
Timbrell, J. A., Introduction to Toxicology. Taylor and Francis, London, 1995; (CS)
Recommended reading
Classification of course in study plans
- Programme NPCP_CHTOZP Master's
branch NPCO_CHTOZP , 1 year of study, winter semester, compulsory
- Programme NKCP_CHTOZP Master's
branch NKCO_CHTOZP , 1 year of study, winter semester, compulsory
- Programme CKCP_CZV lifelong learning
branch CKCO_CZV , 1 year of study, winter semester, compulsory