Course detail

General Toxicology

FCH-BCA_OBTAcad. year: 2012/2013

The science of toxicology. Terminology of toxicology, History. The explanation of the relation of dose - effec, mechamism of toxic effects, factors influencing toxic effects, characteristics of of toxic effects, basic principles. The chemical compounds interaction. Mechanism of chemical compounds penetrating to organism. Toxicologic kinetice (primary contact, absorption, transport, excrection). The biotransformation of toxic compounds, factors influencing the biotransformation. The causation of demage of cells, tissues, organism and species levels. The main types of toxic effects. The evaluation of toxicity. The summary of the toxicology of inorganic and organic elements, compounds. The overview of therapy, antidots. The classification of chemical compounds in CZ and EU, actual legislative. The source of information, the information system of toxicology.

Language of instruction

Czech

Number of ECTS credits

Mode of study

Not applicable.

Guarantor

Mgr. Helena Doležalová Weissmannová, Ph.D.

Department

Institute of Chemistry and Technology of Environmental Protection (ÚCHTOŽP)

Learning outcomes of the course unit

Students will obtained new knowledge, understanding and knowledge in the following areas

1st Students will be able to use the terms in toxicology and other chemical sectors (environmental chemistry, ecotoxicology, etc.)
2nd Students will obtain the knowledge of mechanisms of toxic effects on organisms and they will know the different types of toxic effects.
3rd Students will understand the influence of factors (internal and external) on the toxicity of substances.
4th Students gain knowledge and experience toxic effects of inorganic and organic substances on the organism.
5th Students will understand the current legislative and regulatory documents defining the handling of chemicals.

Prerequisites

Basic principles of bilogy, chemistry and ecology.

Co-requisites

Not applicable.

Planned learning activities and teaching methods

Teaching methods depend on the type of course unit as specified in the article 7 of BUT Rules for Studies and Examinations.

Assesment methods and criteria linked to learning outcomes

Test in the form of written test along with the oral exam in the range of lectures and recommended literature.

Course curriculum

1. The term toxicology within the context of natural sciences, basic definitions, history
2. Toxic effect, factors influenced on toxic effect.
3. Characteristics of toxic effects.
4. Interaction toxic agents and possible damages of organisms on the level of cell, organs, organism, species.
5. Mechanism of intragression of toxic agents into body.

Work placements

Not applicable.

Aims

The aim is to provide and explain the basic concepts in toxicology, to clarify the mechanisms of the effects of pollutants and toxic chemicals at different levels, to explain the factors affecting toxicity. In this course students will get acquainted with the toxic effects of selected inorganic and organic compounds and substances, current legislation and defining documents dealing with chemicals and safety.

Specification of controlled education, way of implementation and compensation for absences

Attendance at lectures is recommended, but not controlled.
An integral part of teaching and combined form of teaching is a e-learning tutorial course, divided into blocks, within which are available to students learning support including electronic textbooks, presentations, lectures, and other complementary materials.
For students in combined form of study are organized consultations on the topics for full-time students.
Consultations are also provided to full-time students on request.

Recommended optional programme components

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

http://toxnet.nlm.nih.gov/ (CS)
Lullman, H., Mohr, K., Wehling, M., Farmakologie a toxikologie, Grada vicenum, 2002 (CS)
Tichý, M., Toxikologie pro chemiky. Universita Karlova, Praha, 2002 (CS)
Timbrell, J. A., Introduction to Toxicology. Taylor and Francis, London, 1995 (CS)

Type of course unit

Lecture

26 hod., optionally

Teacher / Lecturer

Mgr. Helena Doležalová Weissmannová, Ph.D.

Guided consultation in combined form of studies

26 hod., optionally

Teacher / Lecturer

Mgr. Helena Doležalová Weissmannová, Ph.D.