Nanofibers with antimicrobial activity as potential would healing delivery system

lecture

English

Nanofiber-based delivery systems have recently been the focus of increased investigation for wound healing applications, due to their ability to administer active substances directly to the target site, thereby facilitating tissue repair and regenera-tion while preventing infections [1,2]. This study was focused on development of an antimicrobial delivery system utilizing PHB nanofibrous structures and subsequent incorporation of liposomes into nanomaterial mesh. The materials were enriched with phenolic components and antibiotic to enhance antimicrobial protection at the wound site. The nanostructures were fabricated by forcespinnig and a controlled environment in vitro model was established to evaluate the release of the en capsulated substances by HPLC. In addition, the materials were tested for antimicrobial activity against selected strains of microorganisms. To determinate the suitability for local applications, a cell viability assay on HaCat cell line was performed. The results indicated strong antimicrobial activity against selected bacterial strains and pathogenic fungi, while demonstrating no cytotoxic properties. The nanofiber delivery system showed promising potential for localized wound treatment. References [1] B.L. Banik, J.L. Brown, Polymeric Biomaterials in Nanomedicine, Natural and Synthetic Biomedical Polymers (2014) 387–395. https://doi.org/10.1016/B978-0-12-396983-5.00024-7. [2] M. Mohiti-Asli, E.G. Loboa, Nanofibrous smart bandages for wound care, Wound Healing Biomaterials 2 (2016) 483–499. https://doi.org/10.1016/B978-1-78242-456-7.00023-4.

nafiber, wound healing, antimicrobial system

DZURICKÁ, L.; KUNERTOVÁ, A.; KOZLÍČKOVÁ, H.; JANDEROVÁ, Š.; RAPPELLI, P.; MÁROVÁ, I.

22. 1. 2025

Sciendo

22

22

33

https://sciendo.com/de/article/10.2478/ebtj-2025-0003