Publication detail

Comprehensive characterization of natural polysaccharide-based hydrogels with gradient structure in concentration and stiffness

ZINKOVSKA, N. TRUDIČOVÁ, M. MARKOVÁ, K. PEKAŘ, M. SMILEK, J.

Original Title

Type

journal article in Web of Science

Language

English

Original Abstract

Gradient hydrogels are functionally graded biomaterials that over the last decades have garnered significant attention as valuable materials for tissue repair and regeneration. This study elucidates key factors crucially determining the character or pattern of a buoyancy-driven gradient in agarose hydrogels and also provides fundamental information regarding the complex interpretation of the formed gradient hydrogels obtained by the different characterization techniques, including rheology, UV-Vis spectroscopy, FCS, AFM, SEM. The employed techniques were successfully optimized to enhance the understanding of the gradient properties of these hydrogels. Demonstrated results showed that the agarose concentration gradient could be successfully controlled and tailored, which offers a valuable contribution to the design of gradient hydrogel. Moreover, a novel method for determining the average agarose concentration along the gradient axis is presented, improving the precision of gradient characterization. The integration of these approaches significantly enhances the comprehension of the internal structure and properties of gradient materials, contributing to advancements in their understanding and application.

Keywords

Hydrogels, Stiffness gradient, Rheology, Atomic force microscopy, Fluorescence correlation spectroscopy, Polysaccharides

Authors

ZINKOVSKA, N.; TRUDIČOVÁ, M.; MARKOVÁ, K.; PEKAŘ, M.; SMILEK, J.

Released

27. 9. 2024

Publisher

ELSEVIER

Location

Amsterdam

ISBN

0927-7757

Periodical

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Year of study

704

Number

135455

State

Kingdom of the Netherlands

Pages count

URL

https://www.sciencedirect.com/science/article/abs/pii/S0927775724023197

BibTex

@article{BUT190023,
  author="Natalia {Zinkovska} and Monika {Trudičová} and Kateřina {Marková} and Miloslav {Pekař} and Jiří {Smilek}",
  title="Comprehensive characterization of natural polysaccharide-based hydrogels with gradient structure in concentration and stiffness",
  journal="Colloids and Surfaces A: Physicochemical and Engineering Aspects",
  year="2024",
  volume="704",
  number="135455",
  pages="13",
  doi="10.1016/j.colsurfa.2024.135455",
  issn="0927-7757",
  url="https://www.sciencedirect.com/science/article/abs/pii/S0927775724023197"
}