Publication detail
Multilayered cellular skin substitute with biomimetic collagen-chitosan scaffold
SMOLNICKÁ, A. LIPOVÝ, B. PAVLIŇÁKOVÁ, V. HOLOUBEK, J. FALDYNA, M. JEKLOVÁ, E. VOJTOVÁ, L. KOUTNÁ, I.
Original Title
Multilayered cellular skin substitute with biomimetic collagen-chitosan scaffold
Type
abstract
Language
English
Original Abstract
It has been proved that cellular skin substitutes provide faster wound healing and vascularization. Suitable cells for skin substitutes are mesenchymal stromal cells (MSCs), which have anti-inflammatory properties, appropriate differentiation capacity, and promote angiogenesis. MSCs can be differentiated into fibroblasts or preadipocytes. These differentiated cells were seeded on biocompatible and biodegradable collagen-chitosan foams that serve as scaffolds. Fibroblasts cultivated in the scaffold mimic the dermis layer, and preadipocytes imitate the hypodermis. Isolated keratinocytes were seeded on top of the scaffold as an epidermis layer.
Keywords
collagen, chitosan, scaffold, dermis, regenerative medicine
Authors
SMOLNICKÁ, A.; LIPOVÝ, B.; PAVLIŇÁKOVÁ, V.; HOLOUBEK, J.; FALDYNA, M.; JEKLOVÁ, E.; VOJTOVÁ, L.; KOUTNÁ, I.
Released
25. 4. 2024
Location
Praha
ISBN
978-80-01-07293-6
Book
Bioimplantologie a regenerativní medicína 2024
Edition number
1. elektronické
Pages from
45
Pages to
45
Pages count
59
URL
BibTex
@misc{BUT189768,
author="Anna {Smolnická} and Břetislav {Lipový} and Veronika {Pavliňáková} and Jakub {Holoubek} and Martin {Faldyna} and Edita {Jeklová} and Lucy {Vojtová} and Irena {Koutná}",
title="Multilayered cellular skin substitute with biomimetic collagen-chitosan scaffold",
booktitle="Bioimplantologie a regenerativní medicína 2024",
year="2024",
edition="1. elektronické",
pages="45--45",
address="Praha",
isbn="978-80-01-07293-6",
url="https://921c88450d.clvaw-cdnwnd.com/17e12706bb26b88046060a8921d16f31/200000499-73ed673ed8/bioimplantologie_2024_sbornik.pdf?ph=921c88450d",
note="abstract"
}