Publication detail

A Nature-inspired Bilayer Nanofibrous Scaffold Suppressing Inflammation and Improving Skin Regeneration

VOJTOVÁ, L. VERČIMÁKOVÁ, K. PAVLIŇÁKOVÁ, V. HEFKA BLAHNOVÁ, V. FILOVA, E.

Original Title

Type

abstract

Language

English

Original Abstract

Skin wound healing is a complex process involving the interaction of cells, mediators, cytokines, matrix remodeling, and the neurovascular system. The success rate of skin healing has significantly increased with the use of custom-made skin substitutes that mimic the extracellular matrix (ECM) and its properties. Collagen, the most abundant protein in the human body, serves as a structural building block of the ECM in most native tissues. It possesses unique structural properties essential for skin tissue engineering, regulating functional responses while being low-inflammatory, biodegradable, biocompatible, and bioresorbable. Chitosan and oxidized cellulose also exhibit various beneficial biological properties, such as biocompatibility, good interaction with cells, low immunogenicity, and antimicrobial activity. Additionally, pro-healing growth factors and antibacterial catechol additives are known to enhance the biological activity of these materials. In this research, we enriched cross-linked, lyophilized 3D porous collagen-polysaccharide carriers with both pro-healing proteins and antibacterial additives top-coated with bioresorbable nanofiber layer to evaluate their mechanical stability, strength, absorbability, in vitro cytotoxicity, angiogenic, and antibacterial potential. The prepared bilayer scaffold demonstrated ideal hydrolytic and enzymatic stability in vitro, was easy to handle without signs of deformation, and exhibited both antimicrobial and biocompatibility properties necessary for wound healing management.

Keywords

Skin wound healing, collagen, chitosan, oxidized cellulose, antibacterial, prohealing

Authors

VOJTOVÁ, L.; VERČIMÁKOVÁ, K.; PAVLIŇÁKOVÁ, V.; HEFKA BLAHNOVÁ, V.; FILOVA, E.

Released

23. 7. 2024

Publisher

Advanced Materials Sciences and Engineering

Location

Lovran, Croatia

Pages from

Pages to

Pages count

235

BibTex

@misc{BUT189722,
  author="Lucy {Vojtová} and Katarína {Verčimáková} and Veronika {Pavliňáková} and Veronika {Hefka Blahnová} and Eva {Filova}",
  title="A Nature-inspired Bilayer Nanofibrous Scaffold Suppressing Inflammation and Improving Skin Regeneration
",
  booktitle="The 5th International Congress on Advanced Materials Sciences and Engineering, Abstract Book",
  year="2024",
  pages="92--92",
  publisher="Advanced Materials Sciences and Engineering",
  address="Lovran, Croatia",
  note="abstract"
}