Publication detail

Enhanced mechanical properties of hydrogels reinforced with biodegradable microfibers

ČERNÁ, E. VARCHENKO, M. PAVLIŇÁKOVÁ, V. HŘEBÍČEK, T. RŮŽIČKOVÁ, J. VOJTOVÁ, L.

Original Title

Type

abstract

Language

English

Original Abstract

Hydrogel films have gained significant attention due to their versatility in various biomedical applications. Their physical properties can be tuned using natural and synthetic polymers or fibres depending on the final application (acute/chronic skin wounds). Hydrogels are widely used because of their hydrophilic character and ability to form a 3D polymer network while remaining stable and hydrated, which is suitable for moist wound healing. This study investigates the effect of composition and fabrication methods on the mechanical properties of enhancement biopolymer-based hydrogels by incorporating biodegradable, hydrophobic microfibers. Biopolymers/polymers used are biocompatible and known for their hydrophilic nature and excellent film-forming capabilities. They are used together with biocompatible plasticizers to increase elasticity and film transparency. Hydrophobic microfibers have reinforcement potential due to their high tensile strength and modulus. The reinforcement effect of the fibres can be attributed to the homogeneous dispersion and interfacial adhesion of the hydrogel matrix in solution within the microfibers, facilitating load transfer and enhancing structural integrity. Furthermore, incorporating microfibers did not compromise the hydrophilicity of the hydrogel films. Swelling behaviour and hydrolytic degradation were influenced by hydrogel composition and fabrication methods. The most efficient method allowed the fabrication of transparent, hydrolytically stable and mechanically strong hydrogel, offering promising avenues for advanced applications in wound healing management.

Keywords

Hydrogel, transparent, microfiber, biopolymer, mechanical properties

Authors

ČERNÁ, E.; VARCHENKO, M.; PAVLIŇÁKOVÁ, V.; HŘEBÍČEK, T.; RŮŽIČKOVÁ, J.; VOJTOVÁ, L.

Released

25. 4. 2024

Location

Praha, Czech Republic

ISBN

978-80-01-07293-6

Book

XV. mezinárodní konference Bioimplantologie a regenerativní medicína 2024

Edition

Edition number

Pages from

Pages to

Pages count

URL

chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://921c88450d.clvaw-cdnwnd.com/17e12706bb26b88046060a8921d16f31/200000499-73ed673ed8/bioimplantologie_2024_sbornik.pdf?ph=921c88450d

BibTex

@misc{BUT189684,
  author="Eva {Černá} and Marko {Varchenko} and Veronika {Pavliňáková} and Tomáš {Hřebíček} and Jana {Růžičková} and Lucy {Vojtová}",
  title="Enhanced mechanical properties of hydrogels reinforced with biodegradable microfibers",
  booktitle="XV. mezinárodní konference Bioimplantologie a regenerativní medicína 2024",
  year="2024",
  series="1",
  edition="1",
  pages="28--28",
  address="Praha, Czech Republic",
  isbn="978-80-01-07293-6",
  url="chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://921c88450d.clvaw-cdnwnd.com/17e12706bb26b88046060a8921d16f31/200000499-73ed673ed8/bioimplantologie_2024_sbornik.pdf?ph=921c88450d",
  note="abstract"
}