Publication detail
Advanced Freeze-Dried Hydrogel Films for Combatting Bacterial Infections in Chronic Wounds
ČERNÁ, E. BRTNÍKOVÁ, J. LIPOVÝ, B. FOHLEROVÁ, Z. VACEK, L. VOJTOVÁ, L.
Original Title
Advanced Freeze-Dried Hydrogel Films for Combatting Bacterial Infections in Chronic Wounds
Type
abstract
Language
English
Original Abstract
Infected chronic wounds affected by antibiotic-resistant bacteria are a significant global healthcare problem, leading to prolonged patient suffering, increased healthcare costs, and morbidity rates, which demand innovative solutions. This work presents a novel approach using antiseptic-coated gum Karaya/PVA hydrogel films to combat resistant bacterial infections. The freeze-dried films integrate antimicrobial agent within a biocompatible matrix, offering sustained release and prolonged efficacy. The freeze-drying process facilitates the fabrication of the hydrogel films and enables crosslinking within the hydrogel matrix enhancing the mechanical strength and stability of the films, making them more resilient to physical stresses encountered during wound management. Key analyses include hydrogel degradation and mechanical strength, antimicrobial agent release, cytotoxicity, and antibacterial testing. These tests confirm the film's ability to absorb exudates, maintain stability in the hydrated state for up to 30 days, withstand physical stresses needed for easy handling, exhibit biocompatibility and sufficient antimicrobial activity to suppress and eliminate bacterial infection. In conclusion, this technology presents a promising strategy for managing infected chronic wounds, enhancing wound healing, and alleviating the global healthcare burden.
Keywords
Hydrogel, antibacterial, gum Karaya, PVA, antimicrobial agent hydrogel film
Authors
ČERNÁ, E.; BRTNÍKOVÁ, J.; LIPOVÝ, B.; FOHLEROVÁ, Z.; VACEK, L.; VOJTOVÁ, L.
Released
2. 7. 2024
Location
Greece, Thessaloniki
Pages from
152
Pages to
152
Pages count
1
URL
BibTex
@misc{BUT189261,
author="Eva {Černá} and Jana {Brtníková} and Břetislav {Lipový} and Zdenka {Fohlerová} and Lukáš {Vacek} and Lucy {Vojtová}",
title="Advanced Freeze-Dried Hydrogel Films for Combatting Bacterial Infections in Chronic
Wounds",
booktitle="21st International Conference on Nanosciences & Nanotechnologies, Book of Abstract, Greece, Thessaloniki, 2-5 July 2024",
year="2024",
pages="152--152",
address="Greece, Thessaloniki",
url="https://www.nanotexnology.com/index.php/abstract-books-2024/send/5-abstract-books-2024/16-nn24-abstract-book",
note="abstract"
}