Publication detail

Smart Albumin-Based Nanoparticle Delivery System for the Treatment of Infected Burn Wounds

POLÁKOVÁ, V. FOHLEROVÁ, Z. PŘIBYL, J. OBOŘILOVÁ, R. KLIMOVIČ, Š. VOJTOVÁ, L.

Original Title

Type

abstract

Language

English

Original Abstract

Infected burn wounds pose a major challenge in regenerative medicine due to their long healing times, pain, and other health risks like sepsis. The failure of traditional antibiotics against resistant bacteria has led to a focus on developing materials suitable for antibacterial nanoparticle on wound site delivery. However, research on pH-responsive delivery systems for the alkaline conditions of infected wounds is limited. The development of "smart delivery systems" with unique properties (e.g., external stimuli responsiveness) is critical to overcome these issues. Addressing this, our goal was to develop a smart, biocompatible albumin-based hydrogel. It leverages the pH shift to alkaline region, caused by presence of infection in burns, as a stimulus for quicker swelling and antibacterial nanoparticle release. Second was to ensure easy and less painful experience for the patient. Therefore, we aimed to develop sprayable material. The gelation mechanism of this hydrogel is based on carbodiimide crosslinking. Final hydrogel can be applied on wound site by spray, after combining two liquid parts, gelation occurs within 20 minutes. Within this study the effect of glycerol and urea, to improve mechanical properties, was studied. Swelling/degradation kinetics were evaluated according to changes in hydrogel volume in real time using QCM-D in different pH and temperature.

Keywords

Smart hydrogel, swelling, infected burn wounds, pH-responsivness, regenerative medicine

Authors

POLÁKOVÁ, V.; FOHLEROVÁ, Z.; PŘIBYL, J.; OBOŘILOVÁ, R.; KLIMOVIČ, Š.; VOJTOVÁ, L.

Released

2. 7. 2024

Location

Greece, Thessaloniki

Pages from

153

Pages to

153

Pages count

URL

https://www.nanotexnology.com/index.php/abstract-books-2024/send/5-abstract-books-2024/16-nn24-abstract-book

BibTex

@misc{BUT189254,
  author="Veronika {Poláková} and Zdenka {Fohlerová} and Jan {Přibyl} and Radka {Obořilová} and Šimon {Klimovič} and Lucy {Vojtová}",
  title="Smart Albumin-Based Nanoparticle Delivery System for the Treatment of Infected Burn Wounds",
  booktitle="21st International Conference on Nanosciences & Nanotechnologies, Book of Abstract, Greece, Thessaloniki, 2-5 July 2024",
  year="2024",
  pages="153--153",
  address="Greece, Thessaloniki",
  url="https://www.nanotexnology.com/index.php/abstract-books-2024/send/5-abstract-books-2024/16-nn24-abstract-book",
  note="abstract"
}