Publication detail

RNA analysis of the longest living vertebrate Greenland shark revealed an abundance of LINE-like elements in its transcriptome

DOBROVOLNÁ, M. ŠISLEROVÁ, L. BRÁZDA, V. BARTAS, M. ČERVEŇ, J. VALKOVÁ, N. VOLNÁ, A. BALDVINSSON, H. PEČINKA, P.

Original Title

RNA analysis of the longest living vertebrate Greenland shark revealed an abundance of LINE-like elements in its transcriptome

Type

journal article in Web of Science

Language

English

Original Abstract

The Greenland shark (Somniosus microcephalus) is an enigmatic species known for its exceptional longevity and extraordinary adaptations to the cold environment. This animal lives in the arctic and subarctic regions of the North Atlantic Ocean. Surprisingly, even though it is a vertebrate with the longest known lifespan, its transcriptome has not been studied yet. Therefore, we isolated and analyzed RNA in the Greenland shark samples. Our findings reveal some important information about the possible genetic mechanisms that could contribute to its longevity. We identified a highly expressed long interspersed nuclear element-like transcript (LINE-like) that is supposed to be associated with extended lifespan and resilience to age-related diseases, possibly through an improved telomere maintenance mechanism. This research not only contributes to our understanding of the biology and evolution of the Greenland shark but could also have implications for human longevity research.

Keywords

Greenland shark; transcriptome; bioinformatics; LINE -1; longevity research; Somniosus microcephalus

Authors

DOBROVOLNÁ, M.; ŠISLEROVÁ, L.; BRÁZDA, V.; BARTAS, M.; ČERVEŇ, J.; VALKOVÁ, N.; VOLNÁ, A.; BALDVINSSON, H.; PEČINKA, P.;

Released

1. 3. 2024

Publisher

MASARYK UNIV PRESS

Location

Brno

ISBN

1805-0689

Periodical

Czech Polar Reports

Year of study

13

Number

2

State

Czech Republic

Pages from

210

Pages to

227

Pages count

18

URL

https://www.researchgate.net/publication/379016677_RNA_analysis_of_the_longest_living_vertebrate_Greenland_shark_revealed_an_abundance_of_LINE-like_elements_in_its_transcriptome

BibTex

@article{BUT188984,
  author="DOBROVOLNÁ, M. and ŠISLEROVÁ, L. and BRÁZDA, V. and BARTAS, M. and ČERVEŇ, J. and VALKOVÁ, N. and VOLNÁ, A. and BALDVINSSON, H. and 	PEČINKA, P.",
  title="RNA analysis of the longest living vertebrate Greenland shark revealed an abundance of LINE-like elements in its transcriptome",
  journal="Czech Polar Reports",
  year="2024",
  volume="13",
  number="2",
  pages="210--227",
  doi="10.5817/CPR2023-2-17",
  issn="1805-0689",
  url="https://www.researchgate.net/publication/379016677_RNA_analysis_of_the_longest_living_vertebrate_Greenland_shark_revealed_an_abundance_of_LINE-like_elements_in_its_transcriptome"
}