Publication detail

Abundance of G-Quadruplex Forming Sequences in the Hepatitis Delta Virus Genomes

BRÁZDA, V. VÁLKOVÁ, N. DOBROVOLNÁ, M. MERGNY, J.

Original Title

Abundance of G-Quadruplex Forming Sequences in the Hepatitis Delta Virus Genomes

Type

journal article in Web of Science

Language

English

Original Abstract

Hepatitis delta virus (HDV) is a highly unusual RNA satellite virus that depends on the presence of hepatitis B virus (HBV) to be infectious. Its compact and variable single-stranded RNA genome consists of eight major genotypes distributed unevenly across different continents. The significance of noncanonical secondary structures such as G-quadruplexes (G4s) is increasingly recognized at the DNA and RNA levels, particularly for transcription, replication, and translation. G4s are formed from guanine-rich sequences and have been identified in the vast majority of viral, eukaryotic, and prokaryotic genomes. In this study, we analyzed the G4 propensity of HDV genomes by using G4Hunter. Unlike HBV, which has a G4 density similar to that of the human genome, HDV displays a significantly higher number of potential quadruplex-forming sequences (PQS), with a density more than four times greater than that of the human genome. This finding suggests a critical role for G4s in HDV, especially given that the PQS regions are conserved across HDV genotypes. Furthermore, the prevalence of G4-forming sequences may represent a promising target for therapeutic interventions to control HDV replication.

Keywords

G-quadruplex; HDV; Secondary structures

Authors

BRÁZDA, V.; VÁLKOVÁ, N.; DOBROVOLNÁ, M.; MERGNY, J.

Released

9. 1. 2024

Publisher

American Chemical Society

Location

WASHINGTON

ISBN

2470-1343

Periodical

ACS OMEGA

Year of study

9

Number

3

State

United States of America

Pages from

4096

Pages to

4101

Pages count

6

URL

https://pubs.acs.org/doi/10.1021/acsomega.3c09288

Full text in the Digital Library

http://hdl.handle.net/11012/245216

BibTex

@article{BUT187730,
  author="Václav {Brázda} and Natálie {Válková} and Michaela {Dobrovolná} and Jean-Louis {Mergny}",
  title="Abundance of G-Quadruplex Forming Sequences in the Hepatitis Delta Virus Genomes",
  journal="ACS OMEGA",
  year="2024",
  volume="9",
  number="3",
  pages="4096--4101",
  doi="10.1021/acsomega.3c09288",
  issn="2470-1343",
  url="https://pubs.acs.org/doi/10.1021/acsomega.3c09288"
}