Publication detail

Injectable, resorbable, porous bone substitute with controlled release of antimicrobial agents: a novel tool for the treatment of osteomyelitis

VOJTOVÁ, L. MICHLOVSKÁ, L. GRÉZLOVÁ, V. ŠMERKOVÁ, K. KOPEL, P. ADAM, V. HLINÁKOVÁ, K. DIVIŠ, P. LUKÁŠOVÁ, V. RAMPICHOVÁ, M. SUCHÝ, T. BARTOŠ, M. SEDLÁČEK, R. KRTIČKA, M. BALLAY, R. JAHODA, D. MELICHERČÍK, P. VIŠTEJNOVÁ, L. KLEIN, P. MONTUFAR JIMENEZ, E.

Original Title

Injectable, resorbable, porous bone substitute with controlled release of antimicrobial agents: a novel tool for the treatment of osteomyelitis

Type

abstract

Language

English

Original Abstract

The bone substitute consists of alpha-tricalcium phosphate and water solution of thermosensitive, copolymer based on poly(lactic acid), poly(glycolic acid) and poly(ethylene glycol) (PLGA—PEG—PLGA) [2]. The rheological properties during setting were studied in steady mode using controlled-stress rheometer. The microstructure after setting was investigated by scanning electron microscope, the compression test and accelerated degradation study at pH = 2.2 were performed on cement cylinders after 10 days of setting. The cytocompatibility was evaluated using human mesenchymal stem cells (hMSC) by dsDNA and MTS assays and the osteointegration was preliminarily tested in vivo on Wistar rats by filling iatrogenic bone defect in femoral bone. The new bone substitute was doped with 20-170 ppm of SeNPs with the size of about 100 nm and antibacterial properties on Staphylococcus aureus (SA) strain and its methicillin-resistant form (MRSA) were evaluated by disk diffusion method.

Keywords

bone cement, thermosensitive polymer, thixotropic rheological behavior, cytotoxicity, antibacterial test

Authors

VOJTOVÁ, L.; MICHLOVSKÁ, L.; GRÉZLOVÁ, V.; ŠMERKOVÁ, K.; KOPEL, P.; ADAM, V.; HLINÁKOVÁ, K.; DIVIŠ, P.; LUKÁŠOVÁ, V.; RAMPICHOVÁ, M.; SUCHÝ, T.; BARTOŠ, M.; SEDLÁČEK, R.; KRTIČKA, M.; BALLAY, R.; JAHODA, D.; MELICHERČÍK, P.; VIŠTEJNOVÁ, L.; KLEIN, P.; MONTUFAR JIMENEZ, E.

Released

2. 10. 2019

Location

Maastricht, the Netherlands

Pages from

5785

Pages to

5785

URL

https://eors.info/onewebmedia/EORS%202019_Program%20book%20proofs.pdf

BibTex

@misc{BUT181585,
  author="Lucy {Vojtová} and Lenka {Michlovská} and Veronika {Grézlová} and Kristýna {Šmerková} and Pavel {Kopel} and Vojtěch {Adam} and Kristýna {Hlináková} and Pavel {Diviš} and Věra {Lukášová} and Michala {Rampichová} and Tomáš {Suchý} and Martin {Bartoš} and Radek {Sedláček} and Milan {Krtička} and Rastislav {Ballay} and David {Jahoda} and Pavel {Melicherčík} and Lucie {Vištejnová} and Pavel {Klein} and Edgar Benjamin {Montufar Jimenez}",
  title="Injectable, resorbable, porous bone substitute with controlled release of antimicrobial agents: a novel tool for the treatment of osteomyelitis",
  booktitle="EORS 2019, 27th annual meeting 2-4 October 2019, Maastricht, the Netherlands, abstract book",
  year="2019",
  pages="5785--5785",
  address="Maastricht, the Netherlands",
  url="https://eors.info/onewebmedia/EORS%202019_Program%20book%20proofs.pdf",
  note="abstract"
}