Publication detail

Multicomponent hemostatic dressing may improve bleeding stop and wound regeneration

KACVINSKÁ, K. SEDLÁŘ, M. DVOŘÁK, R. SOPUCH, T. VOJTOVÁ, L.

Original Title

Multicomponent hemostatic dressing may improve bleeding stop and wound regeneration

Type

abstract

Language

English

Original Abstract

The presented research focuses on the preparation and characterization of a new hemostatic wound dressing made from various types of chitosan and cellulose. The dressing has the potential to stop bleeding more effectively while overcoming the limitations that remain of traditional wound dressing, such as a low hemostatic effect, a lack of antimicrobial activity, or possible allergic reactions. The fabrication of hemostatic dressing includes mixing individual blends of different materials in different ratios, followed by a freeze-drying process for two days, which produces highly porous and soft foams. The synergy of the materials has improved the absorption capacity in comparison to the original materials. The various concentrations of carboxymethylcellulose (CMC) combined with either oxidized cellulose (OC) or chitosan significantly improved the absorption capacity compared to those of the mixtures without the addition of CMC. Moreover, hemostatic properties are also supported by CMC, but mainly when CMC exists at lower concentrations and when chitosan exists at a higher amount. Various combined multicomponent dressings have shown different effects on the clotting time. The combination of various types of cellulose and chitosan led to optimal values, where each component brings a specific feature to the hemostatic dressing. Furthermore, the hemostatic dressings are evaluated with questions that lead to their stability and morphology. The new dressing will benefit from its multifunctionality of different hemostatic materials, which are easily available and biocompatible. The adhesion of the dressing to the tissue surface and its biodegradation after the required time are believed to greatly accelerate blood stopping and improve wound healing.

Keywords

Hemostasis, wound dressing, blood stop, biopolymers

Authors

KACVINSKÁ, K.; SEDLÁŘ, M.; DVOŘÁK, R.; SOPUCH, T.; VOJTOVÁ, L.

Released

29. 8. 2022

Publisher

Materials Research Society of Serbia

Location

Belgrade

Pages from

160

Pages to

160

Pages count

185

URL

https://www.mrs-serbia.org.rs/index.php/book-of-abstracts-2022

BibTex

@misc{BUT179701,
  author="Katarína {Verčimáková} and Marian {Sedlář} and Radim {Dvořák} and Tomáš {Sopuch} and Lucy {Vojtová}",
  title="Multicomponent hemostatic dressing may improve bleeding stop and wound regeneration",
  year="2022",
  pages="160--160",
  publisher="Materials Research Society of Serbia",
  address="Belgrade",
  url="https://www.mrs-serbia.org.rs/index.php/book-of-abstracts-2022",
  note="abstract"
}