Publication detail

Mucoadhesive Injectable Hydrogel Enriched with Encapsulated Pro-healing Protein for Hard-to-heal Oral Wounds Treatment

KADLECOVÁ, Z. DZUROV, M. LYSÁKOVÁ, K. VOJTOVÁ, L.

Original Title

Mucoadhesive Injectable Hydrogel Enriched with Encapsulated Pro-healing Protein for Hard-to-heal Oral Wounds Treatment

Type

abstract

Language

English

Original Abstract

Extensive wounds at the oral mucosa, formed after plastic or tooth extraction surgeries, are hard-to-heal. Such wounds also heal in a slightly different manner than skin wounds and tend to shrink during the healing process, leading to a speech impediment or distortion of the face shape of the patient. To heal these wounds, injectable mucoadhesive material is an ideal candidate to prevent shrinkage and, at the same time, promote wound closure and regeneration. This work aims to prepare an injectable thermosensitive drug delivery system with mucoadhesive properties enriched with pro-healing protein – stable fibroblast growth factor-2 (FGF2-STAB®), which stimulated re-epithelization and promotes overall tissue regeneration. The mucoadhesive injectable hydrogel is based on poly(lactide-co-glycolide) and poly(ethylene glycol) copolymer (PLGA-PEG-PLGA) functionalized with itaconic anhydride (ITA), which embodies the mucoadhesive functional groups to the polymer, patented by BUT.

Keywords

Liposomes, mucoadhesive hydrogel, protein release, FGF2-STAB, Lysozyme

Authors

KADLECOVÁ, Z.; DZUROV, M.; LYSÁKOVÁ, K.; VOJTOVÁ, L.

Released

1. 9. 2022

Publisher

Marjorie Dufaud, Member of the BIOMAT Young Researchers Board

Location

France

Pages from

383

Pages to

383

Pages count

1

URL

https://www.esbbordeaux2022.org/upload/pdf/eBook_Posters_MaJ-2.pdf

BibTex

@misc{BUT179246,
  author="Zuzana {Kadlecová} and Matej {Dzurov} and Klára {Tušlová} and Lucy {Vojtová}",
  title="Mucoadhesive Injectable Hydrogel Enriched with Encapsulated
Pro-healing Protein for Hard-to-heal Oral Wounds Treatment",
  booktitle="32nd Annual Conference of the European Society for Biomaterials",
  year="2022",
  pages="383--383",
  publisher="Marjorie Dufaud, Member of the BIOMAT Young Researchers Board",
  address="France",
  url="https://www.esbbordeaux2022.org/upload/pdf/eBook_Posters_MaJ-2.pdf",
  note="abstract"
}