Publication detail

A novel approach in control release monitoring of protein-based bioactive substances from injectable PLGA-PEG-PLGA hydrogel

LYSÁKOVÁ, K. HLINÁKOVÁ, K. KUTÁLKOVÁ, K. CHALOUPKOVA, R. ŽÍDEK, J. BRTNÍKOVÁ, J. VOJTOVÁ, L.

Original Title

A novel approach in control release monitoring of protein-based bioactive substances from injectable PLGA-PEG-PLGA hydrogel

Type

journal article in Web of Science

Language

English

Original Abstract

In recent times, autologous fat grafting has emerged as one of the most popular techniques for restoring volume depletion. Although the retention predictability of grafted fat has been improved, the quality of grafted tissue is still unsatisfactory. Unpredictable volume loss and low-fat survival is a major problem after application. Biodegradable PLGA-PEGPLGA (poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)-b-pol (lactic-co-glycolic acid)) hydrogel delivery system enriched with stable fibroblast growth factor 2 (FGF2-STAB®), due to its properties, seems to be attractive material that will help to increase fat life. In this study, the mechanism of FGF2-STAB® release from an injectable thermosensitive and biodegradable PLGA-PEG-PLGA hydrogel was monitored. First-order kinetics were controlled mainly by decreasing the concentration of an active compound in the matrix and, at a later stage, by matrix degradation. Furthermore, the activity of the protein after release from the hydrogel matrix was studied. No loss of FGF2-STAB® activity in the dynamic system after 14 days has been detected. The development of such a drug delivery system appears promising for further use in reconstructive medicine e.g., in mixing with fat graft being the subject of current research.

Keywords

biodegradable polymers, drug delivery system, thermosensitive hydrogel, PLGA-PEG-PLGA copolymer, FGF2-STAB®

Authors

LYSÁKOVÁ, K.; HLINÁKOVÁ, K.; KUTÁLKOVÁ, K.; CHALOUPKOVA, R.; ŽÍDEK, J.; BRTNÍKOVÁ, J.; VOJTOVÁ, L.

Released

3. 6. 2022

Publisher

Budapest University of Technology and Economics

ISBN

1788-618X

Periodical

EXPRESS POLYM LETT

Year of study

16

Number

8

State

Hungary

Pages from

798

Pages to

811

Pages count

14

URL

https://doi.org/10.3144/expresspolymlett.2022.59

BibTex

@article{BUT178162,
  author="Klára {Tušlová} and Kristýna {Hlináková} and Kateřina {Kutálková} and Radka {Chaloupkova} and Jan {Žídek} and Jana {Brtníková} and Lucy {Vojtová}",
  title="A novel approach in control release monitoring of protein-based bioactive substances from injectable PLGA-PEG-PLGA hydrogel",
  journal="EXPRESS POLYM LETT",
  year="2022",
  volume="16",
  number="8",
  pages="798--811",
  doi="10.3144/expresspolymlett.2022.59",
  issn="1788-618X",
  url="https://doi.org/10.3144/expresspolymlett.2022.59"
}