Publication detail

Study of cholesterol’s effect on the properties of catanionic vesicular systems

HAVLÍKOVÁ, M. SZABOVÁ, J. CHANG, C. MRAVEC, F.

Original Title

Type

abstract

Language

English

Original Abstract

This work is focused on the study of properties and stability catanionic vesicles at laboratory temperature. Catanionic vesicles were based on the ion pair amphiphile (IPA), which was prepared by mixing equivalent volumes of aqueous solution HTMAB (hexadecyltrimethylammonium bromide) and SDS (sodium dodecylsulphate). Then the precipitate was obtained and after removal of the counterions of these surfactants, IPA was formed. The residue IPA was denoted as HTMA-DS. To improve stability positively charged double-chained dioctadecyldimethylammonium chloride (DODAC) and cholesterol were added. The total amount of cholesterol was set to 0, 3, 13, 23, 33, 43, 53, 63 and 73 mol.%. In this system, the size distribution was studied using the dynamic light-scattering (DLS) and zeta potential was determined by electrophoretic light-scattering. These standard techniques were supplemented by fluorescence spectroscopy technique. Specifically, generalized polarization (GP) was measured using a Laurdan probe. This probe is sensitive to fluidity and membrane hydration at a particular temperature.

Keywords

ion pair amphiphile, catanionic vesicles, cholesterol, hydration water, generalized polarization

Authors

HAVLÍKOVÁ, M.; SZABOVÁ, J.; CHANG, C.; MRAVEC, F.

Released

6. 9. 2021

Pages from

123

Pages to

123

Pages count

BibTex

@misc{BUT172491,
  author="Martina {Havlíková} and Jana {Szabová} and Chien-Hsiang {Chang} and Filip {Mravec}",
  title="Study of cholesterol’s effect on the properties of catanionic vesicular systems",
  year="2021",
  series="35th Conference of the European Colloid & Interface Society, Book of Abstracts",
  edition="1",
  pages="123--123",
  note="abstract"
}