Publication detail

Bioeconomic polyhydroxyalkanoate (PHA) manufacturing, and factors boosting PHA biosynthesis

KOLLER, M. OBRUČA, S. BRAUNEGG, G.

Original Title

Bioeconomic polyhydroxyalkanoate (PHA) manufacturing, and factors boosting PHA biosynthesis

Type

abstract

Language

English

Original Abstract

Several steps of the process chain to biosynthesize microbialpolyhydroxyalkanoate (PHA) biopolyesters need to be consideredin order to make these auspicious biopolyesters quantitatively andqualitatively competitive on the global plastic market. Selection,adaptation and genetic modification of microbial strains, feedstocksupply, bioreactor design and process regime, and product recov-ery require optimization. Especially the application of robust, fastgrowing and highly productive microbial species for PHA pro-duction using inexpensive carbon-rich feedstocks has become afrequently used strategy towards economically feasible PHA pro-duction. During biosynthesis, exogenous stress factors triggeringPHA accumulation in microbial biomass play a still underestimatedrole. As recently revealed, presence of PHA helps cells to mitigatethe harmful effects of diverse stress factors like osmotic imbal-ance, oxidative challenge or UV-radiation; biotechnologically, onecan deliberately expose bacterial cells to such stress conditions toboost intracellular PHA biosynthesis. From the engineering per-spective, new bioreactors and continuous operation mode increasePHA productivity and customize PHA’s properties. Together withthe application of sustainable techniques to recover PHA frommicrobial biomass, such as using recyclable and eco-friendly sol-vents under extreme extraction conditions, PHA manufacturingcan be configured as entirely green and sustainable bioeconomictechnology.

Keywords

polyhydroxyalkanoates; bio-economics; bacteria

Authors

KOLLER, M.; OBRUČA, S.; BRAUNEGG, G.

Released

1. 11. 2019

Publisher

Elsevier

ISBN

1873-4863

Periodical

JOURNAL OF BIOTECHNOLOGY

Year of study

305

State

Kingdom of the Netherlands

Pages from

4

Pages to

4

Pages count

1

URL

https://reader.elsevier.com/reader/sd/pii/S0168165619301920?token=6C29D68B18EB12E6623BF0303ABD915EB3654003F439A36604C39FBE512E5ED115DDF4DD17D75EBF1078F47C0023EE9D

BibTex

@misc{BUT163454,
  author="KOLLER, M. and OBRUČA, S. and BRAUNEGG, G.",
  title="Bioeconomic polyhydroxyalkanoate (PHA) manufacturing, and factors boosting PHA biosynthesis",
  year="2019",
  journal="JOURNAL OF BIOTECHNOLOGY",
  volume="305",
  pages="4--4",
  publisher="Elsevier",
  doi="10.1016/j.jbiotec.2019.05.028",
  issn="1873-4863",
  url="https://reader.elsevier.com/reader/sd/pii/S0168165619301920?token=6C29D68B18EB12E6623BF0303ABD915EB3654003F439A36604C39FBE512E5ED115DDF4DD17D75EBF1078F47C0023EE9D",
  note="abstract"
}