Publication detail

Hyaluronan Biofilms Reinforced with Partially Deacetylated Chitin Nanowhiskers: Extraction, Fabrication, In-vitro and Antibacterial Properties of Advanced Nanocomposites

ABDELRAHMAN, R. ABDELLATIF, A. ZBONČÁK, M. FRANKOVÁ, J. LEPCIO, P. KOBĚRA, L. STEINHART, M. PAVLIŇÁK, D. SPOTZ, Z. SKLENÁŘOVÁ, R. BRUS, J. JANČÁŘ, J.

Original Title

Type

journal article in Web of Science

Language

English

Original Abstract

Fabrication of nanocomposite biofilms with enhanced mechanical and antibacterial properties was successfully achieved from hyaluronan (HA) and partially deacetylated chitin nanowhiskers (ChNWs) by a casting-evaporation method. The hydrolysis process of chitin showed an important role in the dimensions, stability, and the crystallinity of extracted ChNWs in a timedependent manner. The volume fraction of ChNWs nanofiller varying from (0.001 to 0.5) exhibited a great influence on the mechanical properties of the biofilms (young modulus, strength) was enhanced by the high load-bearing capacity of NWs compared with net HA film. The antibacterial activity of the nanocomposite biofilms exhibited significant bactericidal activity against different types of bacteria (-/+ gram). HA/ChNWs Nanocomposite biofilms did not show any toxicity against normal human dermal fibroblasts (NHDF) and human primary osteogenic sarcoma (Saos-2) cell lines. The new biofilms with unique properties like edibleness, environmental friendliness, high mechanical properties, antibacterial performance, and noncytotoxicity that could be used in skin/bone tissue regenerations, and drug delivery applications.

Keywords

Nanocomposite biofilm, hyaluronan, chitin nanowhiskers, cytotoxicity, bactericidal activity

Authors

ABDELRAHMAN, R.; ABDELLATIF, A.; ZBONČÁK, M.; FRANKOVÁ, J.; LEPCIO, P.; KOBĚRA, L.; STEINHART, M.; PAVLIŇÁK, D.; SPOTZ, Z.; SKLENÁŘOVÁ, R.; BRUS, J.; JANČÁŘ, J.

Released

1. 5. 2020

ISBN

0144-8617

Periodical

Carbohydrate Polymers

Year of study

244

Number

State

United Kingdom of Great Britain and Northern Ireland

Pages from

115951

Pages to

115963

Pages count

URL

https://www.sciencedirect.com/science/article/pii/S0144861720301259

BibTex

@article{BUT162034,
  author="Rasha {Radwan} and Abdelmohsen Moustafa {Abdellatif} and Marek {Zbončák} and Jana {Franková} and Petr {Lepcio} and Libor {Koběra} and Miloš {Steinhart} and David {Pavliňák} and Zdeněk {Spotz} and Renáta {Sklenářová} and Jiří {Brus} and Josef {Jančář}",
  title="Hyaluronan Biofilms Reinforced with Partially Deacetylated Chitin Nanowhiskers:
Extraction, Fabrication, In-vitro and Antibacterial Properties of Advanced Nanocomposites",
  journal="Carbohydrate Polymers",
  year="2020",
  volume="244",
  number="12",
  pages="115951--115963",
  doi="10.1016/j.carbpol.2020.115951",
  issn="0144-8617",
  url="https://www.sciencedirect.com/science/article/pii/S0144861720301259"
}