Publication detail

The effect of hydroxyapatite particle size on viscoelastic properties and calcium release from a thermosensitive triblock copolymer

CHAMRADOVÁ, I. VOJTOVÁ, L. ČÁSTKOVÁ, K. DIVIŠ, P. PETEREK, M. JANČÁŘ, J.

Original Title

The effect of hydroxyapatite particle size on viscoelastic properties and calcium release from a thermosensitive triblock copolymer

Type

journal article in Web of Science

Language

English

Original Abstract

Well-defined Bsmart^ injectable hydrogel based on hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glycolic acid) (PLA/PGA) copolymer (PLGA-PEG-PLGA) gelling at the body temperature was modified by bioactive hydroxyapatite (HAp) in the form of micro-, nano-, and core-shell particles (μ-HAp, n-HAp, and CS-x, respectively) to be applicable as calcium delivery system in bone regeneration. Viscoelastic moduli increased with HAp content as expected. Whereas systems containing μ-HAp or CS-x particles maintained two sol-gel and gel-sol phase transitions, the n-HAp containing system showed only one sol-gel phase transition due to the strong interactions between polymer chain and the n-HAp surface. In vitro, studies proved the controlled uniform release of calcium cations from both CS-x and n-HAp over the 9-day period without any initial burst release.

Keywords

Polymer composites; Smart polymers; Rheology; Hydroxyapatite; Core-shell particles;sol-gel transition

Authors

CHAMRADOVÁ, I.; VOJTOVÁ, L.; ČÁSTKOVÁ, K.; DIVIŠ, P.; PETEREK, M.; JANČÁŘ, J.

Released

2. 1. 2017

Publisher

Springer Berlin Heidelberg

Location

Německo

ISBN

1435-1536

Periodical

Colloid and Polymer Science

Year of study

295

Number

1

State

Federal Republic of Germany

Pages from

107

Pages to

115

Pages count

9

URL

https://link.springer.com/article/10.1007%2Fs00396-016-3983-7

BibTex

@article{BUT130216,
  author="Ivana {Chamradová} and Lucy {Vojtová} and Klára {Částková} and Pavel {Diviš} and Miroslav {Peterek} and Josef {Jančář}",
  title="The effect of hydroxyapatite particle size on viscoelastic properties and calcium release from a thermosensitive triblock copolymer",
  journal="Colloid and Polymer Science",
  year="2017",
  volume="295",
  number="1",
  pages="107--115",
  doi="10.1007/s00396-016-3983-7",
  issn="1435-1536",
  url="https://link.springer.com/article/10.1007%2Fs00396-016-3983-7"
}