Publication detail

Nanoparticles formed by self-assembly of negatively charged hyaluronan and cationic surfactant

PILGROVÁ, T. PEKAŘ, M. HEJNÁ, J.

Original Title

Type

conference paper

Language

English

Original Abstract

Physico-chemical interactions in hyaluronan-surfactant system result in nanoparticles formation which can be used in targeted delivery of hydrophobic active substances. The aim of our study was to prepare hyaluronic acid nanoparticles based on electrostatic interactions with oppositely charged molecules. Particles were investigated using dynamic light scattering and Laser Doppler Velocimetry methods. Size distribution and zeta potential measurement were utilized to explore the formation of complex micelles. Particles size distributions depend on type of solvent, molecular weight of hyaluronan and charge ratio of components of the hyaluronan-surfactant system. Aggregates formation is influenced by preparation of the system. Stability of the micellar particles depends on zeta potential value.

Keywords

hyaluronan, surfactant, nanoparticles, dynamic light scattering, size distribution, zeta potential

Authors

PILGROVÁ, T.; PEKAŘ, M.; HEJNÁ, J.

RIV year

2013

Released

16. 10. 2013

Publisher

TANGER, Ltd., Keltickova 62, 710 00 Ostrava, Czech Republic, EU

Location

Ostrava

ISBN

978-80-87294-47-5

Book

NANOCON 2013 Conference Proceedings

Edition

1st

Pages from

595

Pages to

599

Pages count

URL

http://konsys-t.tanger.cz/files/proceedings/14/reports/1926.pdf

BibTex

@inproceedings{BUT127413,
  author="Tereza {Pilgrová} and Miloslav {Pekař} and Jana {Mourycová}",
  title="Nanoparticles formed by self-assembly of negatively charged hyaluronan and cationic surfactant",
  booktitle="NANOCON 2013 Conference Proceedings",
  year="2013",
  series="1st",
  pages="595--599",
  publisher="TANGER, Ltd., Keltickova 62, 710 00 Ostrava, Czech Republic, EU",
  address="Ostrava",
  isbn="978-80-87294-47-5",
  url="http://konsys-t.tanger.cz/files/proceedings/14/reports/1926.pdf"
}