Publication detail

Preparation and Characterization of Alginate/silver/nicotinamide Nanocomposites for Treating Diabetic Wounds.

MONTESER, A. ABDEL-LATTIF, A. RAMADAN, M. SAHFFIE, N. SLEEM, M. JANČÁŘ, J. HEBEISH, A.

Original Title

Type

journal article in Web of Science

Language

English

Original Abstract

Silver/Alginate/Nicotinamide nanoparticles composite (Ag/Alg/Nic) was prepared and used for the first time to prepare new wound dressing material. Sodium alginate (ALG) was used as reducing and stabilizing agents for preparation of silver nanoparticles (Ag-NPs). Effect of concentrations of alginate (ALG) on the particle size of silver were studied and confirmed by different techniques like UV/Vis spectroscopy, transmission electron microscope (TEM) and dynamic light scattering (DLS). Nonwoven viscous fabrics were used as a carrier for silver/alginate/ nanoparticles composite by impregnated the nonwoven fabrics as per the padding-curing technique. Nicotinamide (Nic) as anti-inflammatory drug entrapped into Ag-NPS/ALG/nonwoven fabrics. Scanning electron microscope and energy dispersive x-ray (SEM-EDX) were used to evaluate the presence of Ag/ALG/Nic nanoparticles composite anchored the nonwoven fabrics. The antibacterial activity of the Ag/ALG/Nic wound dressing material was evaluated against gram negative Escherichia coli (E.coli) and positive bacteria Staphylococcus Aureus (St. Aureus). The wound healing and histological studied were evaluated by using burn diabetic rat animals.

Keywords

nanocomposite, nonwoven fabrics, wound dressing

Authors

MONTESER, A.; ABDEL-LATTIF, A.; RAMADAN, M.; SAHFFIE, N.; SLEEM, M.; JANČÁŘ, J.; HEBEISH, A.

Released

1. 11. 2016

ISBN

0141-8130

Periodical

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Year of study

739-747

Number

State

Kingdom of the Netherlands

Pages from

739

Pages to

747

Pages count

BibTex

@article{BUT126842,
  author="Abdelmohsen Moustafa {Abdellatif} and ahmed {monteser} and mohamed {Ramadan} and nerman {Sahffie} and mona {Sleem} and Josef {Jančář} and ALI {HEBEISH}",
  title="Preparation and Characterization of Alginate/silver/nicotinamide Nanocomposites for Treating Diabetic Wounds.",
  journal="INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES",
  year="2016",
  volume="739-747",
  number="9",
  pages="739--747",
  doi="10.1016/j.ijbiomac.2016.07.050",
  issn="0141-8130"
}