Publication detail

Wound Dressing Material Fabricated from Silver/Hyaluronan Bio-nanocomposite Fiber

ABDEL-LATTIF, A. JANČÁŘ, J.

Original Title

Type

presentation

Language

English

Original Abstract

In-situ formed hyaluronan/silver (HA/Ag) nanoparticles (NPs) were used to prepare composite fibers for the first time. Sodium hyaluronate was dissolved in demineralized water to obtain good solution. Silver nitrate was added at ambient temperature, then the pH slightly was increased to 8 by adding few drops of sodium hydroxide. The in-situ formed HA/Ag-NPs were used to prepare fibers by wet-dry-spinning technique (WDST). The antibacterial performance of medical HA/AgNP fibers were evaluated against gram negative bacterial (E. coli), exhibiting excellent bactericidal activity. The fibers did not show any cytotoxicity against human keratinocyte cell line (HaCaT). In-vivo animal tests indicated that the prepared fiber dressing has excellent healing efficacy compared to the neat HA and greatly accelerated the healing process. Based on our results, the new HA/Ag nonwoven wound dressing can be used in treating wounds and chronic ulcers as well as cell carrier in different biological research and tissue engineering

Keywords

Hyaluronan, in-situ silver, cytotoxicity, wound dressing

Authors

ABDEL-LATTIF, A.; JANČÁŘ, J.

Released

17. 10. 2015

Publisher

Agnieszka Zarzycka

Location

POLAND

Pages from

Pages to

Pages count

BibTex

@misc{BUT118700,
  author="Abdelmohsen Moustafa {Abdellatif} and Josef {Jančář}",
  title="Wound Dressing Material Fabricated from Silver/Hyaluronan Bio-nanocomposite Fiber",
  year="2015",
  pages="12--12",
  publisher="Agnieszka Zarzycka",
  address="POLAND",
  note="presentation"
}