Publication detail

Application of comprehensive two-dimensional gas chromatography with mass spectrometric detection for the analysis of selected drug residues in wastewater and surface water

LACINA, P. MRAVCOVÁ, L. VÁVROVÁ, M.

Original Title

Type

journal article - other

Language

English

Original Abstract

Pharmaceutical residues have become tightly controlled environmental contaminants in recent years, due to their increasing concentration in environmental components. This is mainly caused by their high level of production and everyday consumption. Therefore there is a need to apply new and sufficiently sensitive analytical methods, which can detect the presence of these contaminants even in very low concentrations. This study is focused on the application of a reliable analytical method for the analysis of 10 selected drug residues, mainly from the group of non-steroidal anti-inflammatory drugs (salicylic acid, acetylsalicylic acid, clofibric acid, ibuprofen, acetaminophen, caffeine, naproxen, mefenamic acid, ketoprofen, and dicofenac), in wastewaters and surface waters. This analytical method is based on solid phase extraction, derivatization by N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) and finally analysis by comprehensive two-dimensional gas chromatography with Time-of-Flight mass spectrometric detection (GC-GC-TOF MS). Detection limits ranged from 0.18 to 5 ng/L depending on the compound and selected matrix. The method was successfully applied for detection of the presence of selected pharmaceuticals in the Svratka River and in wastewater from the wastewater treatment plant in Brno-Modrice, Czech Republic. The concentration of pharmaceuticals varied from one to several hundreds of ng/l in surface water and from one to several tens of ug/l in wastewater.

Keywords

non-steroidal anti-inflammatory drugs, solid phase extraction, derivatization, comprehensive two-dimensional gas chromatography, surface water, wastewater

Authors

LACINA, P.; MRAVCOVÁ, L.; VÁVROVÁ, M.

RIV year

2013

Released

1. 1. 2013

ISBN

1001-0742

Periodical

JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA

Year of study

Number

State

People's Republic of China

Pages from

204

Pages to

212

Pages count

BibTex

@article{BUT97558,
  author="Petr {Lacina} and Ludmila {Mravcová} and Milada {Vávrová}",
  title="Application of comprehensive two-dimensional gas chromatography with mass spectrometric detection for the analysis of selected drug residues in wastewater and surface water",
  journal="JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA",
  year="2013",
  volume="25",
  number="1",
  pages="204--212",
  issn="1001-0742"
}