Publication detail

Development and application of the analytical method using GCxGC-TOF MS for the monitoring of wastewater and surface waters in the Czech Republic for presence of selected drug residues

LACINA, P. VÁVROVÁ, M. MRAVCOVÁ, L.

Original Title

Type

abstract

Language

English

Original Abstract

This study is focused on development and application of the analytical method using comprehensive two-dimensional gas chromatography with mass spectrometric detection Time-of-Flight (GCxGC-TOF MS) for the determination of group of acidic drugs in wastewater and surface waters in the Czech Republic. GCxGC-TOF MS is an excellent method for trace and ultra trace analysis of organic compounds, due to its high separation efficiency and sensitivity. Target compounds were selected mainly from the most used group of pharmaceuticals in the Czech Republic – non-steroidal anti-inflammatory drugs (NSAID): salicylic acid, acetylsalicylic acid, clofibric acid, ibuprofen, caffeine, naproxen, mefenamic acid, ketoprofen and diclofenac. Samples of wastewater were collected daily in November 2010 from the influent and effluent of the WWTP in Brno – Modřice. Samples of surface water were collected from significant river streams Svratka and Svitava in October 2010. Solid phase extraction (SPE) was used for extraction and preconcentration of analytes and MSTFA was used for easy and fast derivatization of target analytes. Limits of detection of the analytical method introduced in this study ranged from 0.18 to 5 ng/L depending on specific compound. Recovery of the method varied from 85 to 98 % depending on specific compound and selected matrix. Concentrations of selected pharmaceuticals in wastewater varied from one to several tens of ug/L and in surface water from tens to several hundreds of ng/L.

Keywords

comprehensive two-dimensional gas chromatography, drug residues, wastewater, surface water

Authors

LACINA, P.; VÁVROVÁ, M.; MRAVCOVÁ, L.

Released

29. 4. 2012

Publisher

Univerzita Palackého

Location

Olomouc

ISBN

978-80-244-3047-8

Book

Chemica

Edition number

49S

Pages from

122

Pages to

122

Pages count

BibTex

@misc{BUT91779,
  author="Petr {Lacina} and Milada {Vávrová} and Ludmila {Mravcová}",
  title="Development and application of the analytical method using GCxGC-TOF MS for the monitoring of wastewater and surface waters in the Czech Republic for presence of selected drug residues",
  booktitle="Chemica",
  year="2012",
  edition="49S",
  pages="122--122",
  publisher="Univerzita Palackého",
  address="Olomouc",
  isbn="978-80-244-3047-8",
  note="abstract"
}